INT293463

Context Info Confidence 0.45 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.06 Pain Relevance 0.26

transmembrane transport (Kcnh1)

Anatomy Link Frequency neuron 1 synapses 1 Kcnh1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Neuronal excitability 9 88.88 hyperexcitability 3 85.44 repetitive firing 3 82.52 Action potential 9 77.48 potassium channel 3 49.52 imagery 6 5.00 tetrodotoxin 3 5.00 Pyramidal cell 3 5.00 Hippocampus 3 5.00

Disease Link Frequency Relevance Heat Neurological Disease 3 63.04 Channelopathies 3 35.52 Infection 6 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, the diffusion coefficient of Eag1 was not affected by disruption of F-actin.

Neg (not) Regulation (affected) of Eag1

1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810327 Disease Relevance 0 Pain Relevance 0

Interestingly, the majority of the regulatory effects described in this study exclusively affect the mobility of Eag1 inside synapses, which strongly indicates a sophisticated regulation for the dynamics of Eag1 channels once these channels enter synaptic terminals.

Regulation (affect) of Eag1 in synapses

2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810327 Disease Relevance 0.06 Pain Relevance 0.17

Finally, we can not exclude the possibility that cytoskeletal elements might play a role in regulating the number of Eag1 channels and/or altering the subunit composition of the complexes that are labeled with a single QD in our study [30], Neuronal electrical properties depend on the activation of ion channels at the appropriate location within the neuron [2].

Regulation (regulating) of Eag1 in neuron

3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810327 Disease Relevance 0 Pain Relevance 0.09

General Comments

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