INT293463

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.06
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Kcnh1)
Anatomy Link Frequency
neuron 1
synapses 1
Kcnh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuronal excitability 9 88.88 High High
hyperexcitability 3 85.44 High High
repetitive firing 3 82.52 Quite High
Action potential 9 77.48 Quite High
potassium channel 3 49.52 Quite Low
imagery 6 5.00 Very Low Very Low Very Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
Pyramidal cell 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurological Disease 3 63.04 Quite High
Channelopathies 3 35.52 Quite Low
Infection 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the diffusion coefficient of Eag1 was not affected by disruption of F-actin.
Neg (not) Regulation (affected) of Eag1
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810327 Disease Relevance 0 Pain Relevance 0
Interestingly, the majority of the regulatory effects described in this study exclusively affect the mobility of Eag1 inside synapses, which strongly indicates a sophisticated regulation for the dynamics of Eag1 channels once these channels enter synaptic terminals.
Regulation (affect) of Eag1 in synapses
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810327 Disease Relevance 0.06 Pain Relevance 0.17
Finally, we can not exclude the possibility that cytoskeletal elements might play a role in regulating the number of Eag1 channels and/or altering the subunit composition of the complexes that are labeled with a single QD in our study [30], Neuronal electrical properties depend on the activation of ion channels at the appropriate location within the neuron [2].
Regulation (regulating) of Eag1 in neuron
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810327 Disease Relevance 0 Pain Relevance 0.09

General Comments

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