INT293468

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Context Info
Confidence 0.78
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.09
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Kcnh1)
Anatomy Link Frequency
pyramidal cells 1
synapses 1
hippocampus 1
Kcnh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 7 98.68 Very High Very High Very High
Pyramidal cell 7 95.48 Very High Very High Very High
potassium channel 7 60.72 Quite High
Neuronal excitability 21 51.52 Quite High
imagery 14 39.36 Quite Low
tetrodotoxin 7 8.72 Low Low
Action potential 21 5.00 Very Low Very Low Very Low
hyperexcitability 7 5.00 Very Low Very Low Very Low
repetitive firing 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 14 88.76 High High
Neurological Disease 7 5.00 Very Low Very Low Very Low
Channelopathies 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antibody revealed the expression of Eag1 in different regions of the rat hippocampus.
Gene_expression (expression) of Eag1 in hippocampus associated with hippocampus
1) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810327 Disease Relevance 0 Pain Relevance 0.05
Accordingly, electron microcopy studies confirmed that Eag1 channels were present at the presynaptic membrane of CA1 Schaffer collaterals facing the postsynaptic membrane of dendritic spines of pyramidal cells (Fig 1D).
Gene_expression (present) of Eag1 in pyramidal cells associated with pyramidal cell
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810327 Disease Relevance 0 Pain Relevance 0.08
Hippocampal cultures were immunolabeled using antibodies against Eag1 channels (mAb62; 10 µg/ml), Tau (Santa Cruz, 1?
Gene_expression (channels) of Eag1
3) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810327 Disease Relevance 0 Pain Relevance 0
Next, we characterized the expression pattern and subcellular distribution of endogenous Eag1 in our hippocampal cultures.
Gene_expression (expression) of Eag1
4) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810327 Disease Relevance 0 Pain Relevance 0.05
Importantly, we measured similar diffusion characteristics for the mobility of Eag1 channels when Munc-13-eGFP was used as a presynaptic marker instead of FM 4-64 (median?
Gene_expression (channels) of Eag1
5) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810327 Disease Relevance 0.09 Pain Relevance 0
In contrast, depolymerization of microtubules after Nocodazole treatment increased the diffusion of Eag1 channels outside synapses (median?
Gene_expression (channels) of Eag1 in synapses
6) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810327 Disease Relevance 0 Pain Relevance 0.06
Furthermore, colocalization with Synaptophysin demonstrated that 25% of axonal Eag1 was present in the membrane of presynaptic terminals (Fig. 1C and quantification in 4A).
Gene_expression (present) of Eag1
7) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810327 Disease Relevance 0 Pain Relevance 0.08

General Comments

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