INT293480

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Context Info
Confidence 0.65
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.82
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90aa1) protein folding (Hsp90aa1) cytosol (Hsp90aa1)
ATPase activity (Hsp90aa1) intracellular (Hsp90aa1) response to stress (Hsp90aa1)
Hsp90aa1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 54 75.96 Quite High
alcohol 6 64.20 Quite High
Hippocampus 9 57.12 Quite High
antidepressant 30 40.88 Quite Low
Glutamate 18 5.00 Very Low Very Low Very Low
Eae 15 5.00 Very Low Very Low Very Low
Nerve growth factor 12 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
ischemia 9 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 19 98.94 Very High Very High Very High
Cancer 58 97.00 Very High Very High Very High
Neurodegenerative Disease 9 56.88 Quite High
Apoptosis 50 53.88 Quite High
Ganglion Cysts 24 48.08 Quite Low
Anxiety Disorder 69 35.60 Quite Low
Targeted Disruption 30 8.60 Low Low
Neurological Disease 12 7.12 Low Low
Death 12 5.00 Very Low Very Low Very Low
Stroke 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, in comparison with control experiments, PU-H71 inhibition of Hsp90 and degradation of HER2/neu results in approximately 50% decrease in 89Zr-DFO-trastuzumab tumor uptake at 24 and 72 h (Table S2; Control-to-PU-H71-treated %ID/g ratios of 2.17 [P?
Protein_catabolism (degradation) of Hsp90 associated with cancer
1) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.41 Pain Relevance 0
Gedunin was recently shown to manifest anticancer activity via inhibition of the 90 kDa heat shock protein (Hsp90) folding machinery and to induce the degradation of Hsp90-dependent client proteins similar to other Hsp90 inhibitors.
Protein_catabolism (degradation) of Hsp90-dependent associated with shock
2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.21 Pain Relevance 0.07
Gedunin, a tetranortriterpenoid isolated from the Indian neem tree (Azadirachta indica), and was recently shown to manifest anticancer activity via inhibition of the 90 kDa heat shock protein (Hsp90) folding machinery and to induce the degradation of Hsp90-dependent client proteins similar to other Hsp90 inhibitors [20], [21], [22], [23], [40].
Protein_catabolism (degradation) of Hsp90-dependent associated with shock
3) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.10 Pain Relevance 0.12
Gedunin, a tetranortriterpenoid isolated from the Indian neem tree (Azadirachta indica), and was recently shown to manifest anticancer activity via inhibition of the 90 kDa heat shock protein (Hsp90) folding machinery and to induce the degradation of Hsp90-dependent client proteins similar to other Hsp90 inhibitors [20], [21], [22], [23], [40].
Protein_catabolism (degradation) of Hsp90 associated with shock
4) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.10 Pain Relevance 0.13

General Comments

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