INT293481

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Raf1) signal transduction (Raf1) plasma membrane (Raf1)
cytoskeleton organization (Raf1) kinase activity (Raf1) cytoplasm (Raf1)
Raf1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 18 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
positron emission tomography 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 4 99.92 Very High Very High Very High
Cancer 116 77.12 Quite High
Breast Cancer 6 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Aggression 2 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
0.25 ┬ÁM, decreased expression levels of Hsp90 client onco-proteins including HER2/neu, Akt and RAF1, compared to DMSO-treated controls.
Negative_regulation (decreased) of Gene_expression (expression) of RAF1
1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.16 Pain Relevance 0
Decreased expression levels of RAF1 demonstrate that PU-H71 inhibition of Hsp90 also inhibits the MAPK signaling pathway, consequently suppressing the transcription of genes associated with cell survival, angiogenesis, proliferation, migration, mitosis, and differentiation.
Negative_regulation (Decreased) of Gene_expression (expression) of RAF1
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.22 Pain Relevance 0

General Comments

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