INT293487

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 3.40
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Erbb2) plasma membrane (Erbb2) nucleus (Erbb2)
kinase activity (Erbb2) cytoplasm (Erbb2)
Anatomy Link Frequency
A549 2
Erbb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 228 99.98 Very High Very High Very High
imagery 23 97.42 Very High Very High Very High
Central nervous system 4 75.76 Quite High
Cannabinoid receptor 28 65.04 Quite High
agonist 28 61.68 Quite High
Inflammation 4 56.96 Quite High
Pain 4 56.40 Quite High
metalloproteinase 20 49.20 Quite Low
antagonist 8 18.16 Low Low
positron emission tomography 10 17.04 Low Low
Disease Link Frequency Relevance Heat
Lung Cancer 27 99.64 Very High Very High Very High
Death 8 98.40 Very High Very High Very High
Cancer 527 98.24 Very High Very High Very High
Apoptosis 42 97.64 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 18 94.72 High High
Breast Cancer 143 78.24 Quite High
Hyperplasia 2 63.24 Quite High
Appetite Loss 4 57.68 Quite High
INFLAMMATION 4 56.96 Quite High
Pain 4 56.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Trastuzumab and related mAb-fragments have been radiolabeled with a wide range of radionuclides and quantitative immunoPET imaging has been used to monitor the effect of administering Hsp90 inhibitors on HER2/neu expression levels.[19]–[30] Quantification of changes in HER2/neu expression in response to Hsp90 treatment has the potential to facilitate patient-specific dose regimes.
Regulation (changes) of Gene_expression (expression) of HER2/neu associated with imagery
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.24 Pain Relevance 0.05
To assess whether cannabinoids modulate the expression of endogenous ErbB2 and of the rat ErbB2 ortologue neu, which is ectopically expressed in our animal model, we conducted real-time quantitative PCR determinations upon THC and JWH-133 treatment.
Spec (whether) Regulation (modulate) of Gene_expression (expressed) of neu associated with cannabinoid
2) Confidence 0.44 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2917429 Disease Relevance 0.55 Pain Relevance 0.23
Alteration of the EGFR/HER-2 receptors and downstream signaling cascades by lapatinib results in apoptosis induction in A549 cells
Regulation (Alteration) of Gene_expression (receptors) of HER-2 in A549 associated with apoptosis
3) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.45 Pain Relevance 0
To assess whether cannabinoids modulate the expression of endogenous ErbB2 and of the rat ErbB2 ortologue neu, which is ectopically expressed in our animal model, we conducted real-time quantitative PCR determinations upon THC and JWH-133 treatment.
Spec (whether) Regulation (modulate) of Gene_expression (expression) of ErbB2 associated with cannabinoid
4) Confidence 0.39 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2917429 Disease Relevance 0.54 Pain Relevance 0.23
To assess whether cannabinoids modulate the expression of endogenous ErbB2 and of the rat ErbB2 ortologue neu, which is ectopically expressed in our animal model, we conducted real-time quantitative PCR determinations upon THC and JWH-133 treatment.
Spec (whether) Regulation (modulate) of Gene_expression (expression) of ErbB2 associated with cannabinoid
5) Confidence 0.29 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2917429 Disease Relevance 0.53 Pain Relevance 0.23
Expression levels of HER2/neu were modulated during the first 24 and 48 h post-administration (29.75±4.43%ID/g and 41.42±3.64%ID/g, respectively).
Regulation (modulated) of Gene_expression (Expression) of HER2/neu
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2810330 Disease Relevance 0.19 Pain Relevance 0
These animals express the rat ErbB2 oncogene (neu) under the control of the hormone-sensitive mouse mammary tumor virus-long terminal repeat (MMTV-LTR) promoter [9].
Regulation (under) of Gene_expression (express) of neu associated with cancer
7) Confidence 0.26 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2917429 Disease Relevance 0.89 Pain Relevance 0.34

General Comments

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