INT293493

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hsp90aa1, Erbb2) unfolded protein binding (Hsp90aa1) intracellular (Hsp90aa1)
response to stress (Hsp90aa1) cytosol (Hsp90aa1) protein folding (Hsp90aa1)
Anatomy Link Frequency
BT-474 2
Hsp90aa1 (Mus musculus)
Erbb2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 9 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
positron emission tomography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 58 100.00 Very High Very High Very High
Apoptosis 2 31.12 Quite Low
Breast Cancer 3 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Aggression 1 5.00 Very Low Very Low Very Low
Shock 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In HER2/neu positive tumors, Hsp90 has been shown to regulate the expression levels of a variety of onco-proteins including HER2/neu.[18], [57] In vitro Western blot studies showed that treatment of BT-474 cells with varying concentrations of PU-H71 (1–0.01 µM, Figure S3) for 24 h led to changes in expression levels of proteins associated with the ERBB signaling cascade (Figure 2).
Hsp90 Regulation (regulate) of Gene_expression (expression) of HER2/neu in BT-474 associated with cancer
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.10 Pain Relevance 0

General Comments

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