INT2935

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Context Info
Confidence 0.24
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.07
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (AGL) transferase activity, transferring glycosyl groups (AGL) carbohydrate metabolic process (AGL)
cytoplasm (AGL) cytosol (AGL) hydrolase activity, acting on glycosyl bonds (AGL)
Anatomy Link Frequency
plasma 2
liver 2
AGL (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 3 96.68 Very High Very High Very High
Paracetamol 2 59.16 Quite High
addiction 8 40.32 Quite Low
Inflammation 17 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 14 98.82 Very High Very High Very High
Obesity 10 97.54 Very High Very High Very High
Pain 1 96.68 Very High Very High Very High
Cancer 129 95.44 Very High Very High Very High
Diabetes Mellitus 25 82.80 Quite High
Colon Cancer 1 76.24 Quite High
Hyperglycemia 52 62.44 Quite High
Fatigue 5 20.16 Low Low
Hypoglycemia 4 18.68 Low Low
Ovarian Cancer 59 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study demonstrates that in obese males physiological levels of FFA contribute to the retention of hepatic glycogen during short-term fasting by inhibiting breakdown of glycogen and increasing glycogen synthesis retained as glycogen, whereas in lean males this effect was absent due to unaltered glycogen synthesis retained as glycogen.
Negative_regulation (breakdown) of Gene_expression (synthesis) of glycogen associated with obesity
1) Confidence 0.24 Published 2004 Journal Metab. Clin. Exp. Section Abstract Doc Link 15254882 Disease Relevance 0.31 Pain Relevance 0.06
Experimental evidence also suggests that midrace fueling extends endurance capacity by increasing the proportion of oxidized carbohydrate derived from plasma glucose as opposed to intramuscular glycogen [31], and correspondingly reducing the rate of intramuscular glycogen depletion [32].
Negative_regulation (reducing) of Gene_expression (depletion) of glycogen in plasma
2) Confidence 0.16 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2958805 Disease Relevance 0 Pain Relevance 0
The stress was accompanied by mobilization of the glycogen deposits; glycogen synthesis in liver tissue and oxidation of pyruvate, asparate succinate or alpha-ketoglutarate in tricarboxylic acid cycle were inhibited.
Negative_regulation (inhibited) of Gene_expression (synthesis) of glycogen in liver associated with stress
3) Confidence 0.02 Published 1978 Journal Vopr. Med. Khim. Section Abstract Doc Link 569922 Disease Relevance 0.55 Pain Relevance 0.17
Nigam et al. concluded that low glycogen was due to defective glycogen synthesis and reported low activities of key glyconeogenic enzymes phosphoglucomutase and glycogen synthetase as compared to normal tissues [24].
Negative_regulation (defective) of Gene_expression (synthesis) of glycogen
4) Confidence 0.01 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2825545 Disease Relevance 1.21 Pain Relevance 0

General Comments

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