INT29352

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Context Info
Confidence 0.58
First Reported 1986
Last Reported 2009
Negated 2
Speculated 1
Reported most in Abstract
Documents 16
Total Number 20
Disease Relevance 6.51
Pain Relevance 14.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprd1) plasma membrane (Oprd1) cytoplasm (Oprd1)
signal transducer activity (Oprd1)
Anatomy Link Frequency
NG108-15 1
brain 1
Oprd1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 155 100.00 Very High Very High Very High
Delta opioid receptors 47 100.00 Very High Very High Very High
agonist 26 100.00 Very High Very High Very High
antagonist 13 100.00 Very High Very High Very High
Antinociceptive 11 99.98 Very High Very High Very High
tetrodotoxin 2 99.84 Very High Very High Very High
Enkephalin 24 99.76 Very High Very High Very High
Analgesic 13 99.68 Very High Very High Very High
MU agonist 3 99.26 Very High Very High Very High
Opioid 69 99.14 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 119 99.70 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 305 99.60 Very High Very High Very High
Convulsion 3 99.56 Very High Very High Very High
Intraoperative Complications 1 99.38 Very High Very High Very High
Diabetes Mellitus 11 99.24 Very High Very High Very High
Nociception 6 98.92 Very High Very High Very High
Drug Dependence 46 97.80 Very High Very High Very High
Glioma 2 97.50 Very High Very High Very High
Neuroblastoma 3 97.24 Very High Very High Very High
Pain 2 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In sharp contrast, mice lacking the Oprd1 gene were more impulsive than controls.
Negative_regulation (lacking) of Oprd1
1) Confidence 0.58 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2635474 Disease Relevance 0.61 Pain Relevance 0.45
Previous experiments have shown that mice lacking a functional delta-opioid receptor (DOR-1) gene do not develop analgesic tolerance to morphine.
Negative_regulation (lacking) of DOR-1 associated with analgesic, tolerance, opioid receptor and morphine
2) Confidence 0.43 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12486185 Disease Relevance 0.43 Pain Relevance 0.89
Previous experiments have shown that mice lacking a functional delta-opioid receptor (DOR-1) gene do not develop analgesic tolerance to morphine.
Negative_regulation (lacking) of delta-opioid receptor associated with analgesic, tolerance, opioid receptor and morphine
3) Confidence 0.43 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12486185 Disease Relevance 0.43 Pain Relevance 0.89
Unlike mu-opioid receptor knockout mutants, mice lacking the delta opioid receptor gene (Oprd1?
Negative_regulation (lacking) of Oprd1 associated with targeted disruption and opioid receptor
4) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635474 Disease Relevance 0.89 Pain Relevance 1.24
We examine, for the first time, the role of opioid systems in impulsivity by testing whether inactivation of the mu- (Oprm1) or delta- (Oprd1) opioid receptor gene alters motor impulsivity in mice.
Spec (whether) Negative_regulation (inactivation) of Oprd1 associated with opioid receptor, attention deficit hyperactivity disorder and opioid
5) Confidence 0.43 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2635474 Disease Relevance 0.90 Pain Relevance 0.46
In sum, mice lacking mu-opioid receptors were significantly better at inhibiting a motor response, whereas mice lacking the delta-opioid receptor were significantly worse.
Negative_regulation (lacking) of delta-opioid receptor associated with mu opioid receptor and opioid receptor
6) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635474 Disease Relevance 0.15 Pain Relevance 0.10
Unlike mu-opioid receptor knockout mutants, mice lacking the delta opioid receptor gene (Oprd1?
Negative_regulation (lacking) of delta opioid receptor associated with targeted disruption and opioid receptor
7) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635474 Disease Relevance 0.89 Pain Relevance 1.24
These data demonstrate that DOR mRNA levels are not altered during and after chronic naltrexone treatment and therefore are not associated with opioid-induced DOR up-regulation or DOR functional supersensitivity.
Neg (not) Negative_regulation (altered) of DOR mRNA associated with opioid receptor and opioid
8) Confidence 0.42 Published 1995 Journal Brain Res. Section Abstract Doc Link 8590066 Disease Relevance 0 Pain Relevance 0.84
The time course of the agonist-induced decrease of delta-opioid receptor dimers is shorter than the time course of internalization, suggesting that monomerization precedes the agonist-induced internalization of the receptor.
Negative_regulation (decrease) of delta-opioid receptor associated with agonist and opioid receptor
9) Confidence 0.40 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341132 Disease Relevance 0 Pain Relevance 0.84
Delta-opioid receptor blockade increases seizure severity, suggesting a predominantly anticonvulsant nature of the delta-opioid system in the seizure model tested here.
Negative_regulation (blockade) of Delta-opioid receptor associated with convulsion, anticonvulsant, opioid receptor and opioid
10) Confidence 0.33 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2829000 Disease Relevance 0.36 Pain Relevance 0.56
Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor.
Negative_regulation (reduced) of delta-opioid receptor associated with analgesic and opioid receptor
11) Confidence 0.28 Published 1998 Journal J. Neurosci. Section Title Doc Link 9736649 Disease Relevance 0 Pain Relevance 0.84
Antinociceptive effects of the selective non-peptidic delta-opioid receptor agonist TAN-67 in diabetic mice.
Negative_regulation (effects) of delta-opioid receptor associated with diabetes mellitus, agonist, opioid receptor and antinociceptive
12) Confidence 0.25 Published 1995 Journal Eur. J. Pharmacol. Section Title Doc Link 7781682 Disease Relevance 0.62 Pain Relevance 0.67
The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins.
Negative_regulation (decrease) of delta-opioid receptor mRNA associated with nociception, analgesic, enkephalin, opioid receptor, ultiva and intraoperative complications
13) Confidence 0.17 Published 2009 Journal Pain Section Title Doc Link 19058913 Disease Relevance 0.70 Pain Relevance 1.58
Glycosylation resulted in a slight decrease in affinity to the delta-opioid receptor, and mixed effect on binding to the mu-opioid receptor.
Negative_regulation (decrease) of delta-opioid receptor associated with opioid receptor
14) Confidence 0.17 Published 2000 Journal Brain Res. Section Abstract Doc Link 11033091 Disease Relevance 0.07 Pain Relevance 0.69
A subtraction cDNA library was constructed from control hybrid NG108-15 (mouse neuroblastoma x rat glioma) cells and NG108-15 cells which had been treated for 48 h with the delta-opioid agonist D-Ala2-D-Leu5 enkephalin (DADLE) to down-regulate the delta-opioid receptor on these cells.
Negative_regulation (down-regulate) of delta-opioid receptor in NG108-15 associated with neuroblastoma, mu agonist, opioid receptor, enkephalin and glioma
15) Confidence 0.16 Published 1995 Journal Gene Section Abstract Doc Link 7835705 Disease Relevance 0.47 Pain Relevance 0.25
MK-801 and LY 235959 reverse delta1- and delta2-opioid receptor agonists-induced down-regulation of brain delta1-opioid receptor, respectively, apparently by different mechanisms.
Negative_regulation (down-regulation) of delta2-opioid in brain associated with agonist and opioid receptor
16) Confidence 0.07 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9369369 Disease Relevance 0 Pain Relevance 1.13
After nBOR inactivation, changes in direction preference were observed for only one of 18 LM units.
Negative_regulation (inactivation) of nBOR
17) Confidence 0.06 Published 2003 Journal J. Neurophysiol. Section Abstract Doc Link 12611994 Disease Relevance 0 Pain Relevance 0.10
We recorded the directional and spatio-temporal tuning of LM units in pigeons before and after nBOR was inactivated by tetrodotoxin injection.
Negative_regulation (inactivated) of nBOR associated with tetrodotoxin
18) Confidence 0.06 Published 2003 Journal J. Neurophysiol. Section Abstract Doc Link 12611994 Disease Relevance 0 Pain Relevance 0.10
Furthermore, analgesic effect of [D.Ala2]deltorphin-I was antagonized by pretreatment with naltrexone but not by naltrindole, a selective antagonist of delta-opioid receptors.
Neg (not) Negative_regulation (antagonist) of delta-opioid associated with antagonist, analgesic and delta opioid receptors
19) Confidence 0.05 Published 1993 Journal Neuropeptides Section Abstract Doc Link 8247256 Disease Relevance 0 Pain Relevance 0.73
This effect was specific to the mu-opioid receptor because delta-opioid receptor desensitization was unaffected by PKCI.
Negative_regulation (desensitization) of delta-opioid receptor associated with opioid receptor
20) Confidence 0.02 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15496510 Disease Relevance 0 Pain Relevance 1.04

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