INT29354

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1986
Last Reported 2001
Negated 2
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.72
Pain Relevance 5.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRK1) signal transducer activity (OPRK1)
Anatomy Link Frequency
brain 4
sensory nerves 2
OPRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 12 100.00 Very High Very High Very High
narcan 9 99.84 Very High Very High Very High
Enkephalin 7 99.84 Very High Very High Very High
Analgesic 3 99.84 Very High Very High Very High
Immobilon 2 99.84 Very High Very High Very High
Opioid 14 99.68 Very High Very High Very High
orphanin 10 99.42 Very High Very High Very High
Dynorphin 9 98.78 Very High Very High Very High
Morphine 2 98.64 Very High Very High Very High
opioid receptor 7 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 18 99.50 Very High Very High Very High
Nociception 1 98.28 Very High Very High Very High
Stress 2 84.16 Quite High
Urological Neuroanatomy 1 65.88 Quite High
Dementia 2 58.52 Quite High
INFLAMMATION 3 52.24 Quite High
Cognitive Disorder 1 42.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Limbic regions of the brain of Alzheimer's disease patients show selective changes in mu, delta and kappa opioid receptor binding.
Regulation (changes) of kappa opioid receptor Binding (binding) of in brain associated with kappa opioid receptor and disease
1) Confidence 0.60 Published 1986 Journal NIDA Res. Monogr. Section Title Doc Link 2829002 Disease Relevance 0.46 Pain Relevance 0.33
Selective changes in mu, delta and kappa opioid receptor binding in certain limbic regions of the brain in Alzheimer's disease patients.
Regulation (changes) of kappa opioid receptor Binding (binding) of in brain associated with kappa opioid receptor and disease
2) Confidence 0.44 Published 1987 Journal Brain Res. Section Title Doc Link 3032356 Disease Relevance 0.49 Pain Relevance 0.35
The present study considered this possibility by examining the effect of GHB on mu, delta, and kappa-opioid receptor binding in concentrations of 1 nM-0.1 mM.
Spec (examining) Regulation (effect) of kappa-opioid receptor Binding (binding) of associated with kappa opioid receptor
3) Confidence 0.19 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8823749 Disease Relevance 0 Pain Relevance 0.97
Lack of effect of gamma-hydroxybutyrate on mu, delta and kappa opioid receptor binding.
Regulation (effect) of kappa opioid receptor Binding (binding) of associated with analgesic and kappa opioid receptor
4) Confidence 0.19 Published 1996 Journal Neurosci. Lett. Section Title Doc Link 8823749 Disease Relevance 0 Pain Relevance 1.24
The experimental data clearly demonstrate that opioids (alkaloids as well as peptides) are able to inhibit nociception arising from inflamed tissue by a local peripheral action. mu- and delta- as well as kappa-opioid receptor ligands are effective by interaction with the respective opioid receptors presumably located in the terminal region of the sensory nerves.
Regulation (effective) of kappa-opioid receptor Binding (ligands) of in sensory nerves associated with nociception, kappa opioid receptor, opioid receptor and opioid
5) Confidence 0.18 Published 1995 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 7668152 Disease Relevance 0.30 Pain Relevance 0.63
Levels of mu- delta- and kappa-opioid receptor binding are unaltered in the caudate, parahippocampal gyrus and occipito-temporal gyrus.
Regulation (unaltered) of kappa-opioid receptor Binding (binding) of associated with kappa opioid receptor
6) Confidence 0.16 Published 2001 Journal Brain Res. Section Abstract Doc Link 11223000 Disease Relevance 0.47 Pain Relevance 0.61
Extracti-Gel D chromatography had little or no effect on the apparent equilibrium dissociation constant for [3H]U-69,593 binding to the kappa 1 receptor.
Neg (little) Regulation (effect) of kappa 1 receptor Binding (binding) of
7) Confidence 0.13 Published 1993 Journal J. Neurosci. Methods Section Abstract Doc Link 8152245 Disease Relevance 0 Pain Relevance 0.12
Replacement of as many as eleven residues in the C-terminus of dynorphin by the corresponding nociceptin sequence has no significant effect on binding and biological activity towards the kappa-opioid receptor.
Neg (no) Regulation (effect) of kappa-opioid receptor Binding (binding) of associated with dynorphin, orphanin and kappa opioid receptor
8) Confidence 0.02 Published 1997 Journal FEBS Lett. Section Abstract Doc Link 9409745 Disease Relevance 0 Pain Relevance 0.80

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox