INT293552

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp6) transmembrane transport (Aqp6)
Anatomy Link Frequency
inner ear 2
Aqp6 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 60 99.50 Very High Very High Very High
imagery 4 30.48 Quite Low
cINOD 8 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 8 22.92 Low Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Tinnitus 8 5.00 Very Low Very Low Very Low
Stress 8 5.00 Very Low Very Low Very Low
Deafness 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AQP6 mRNA expression and protein labeling of the organ of Corti are dramatically reduced after treatment with aspirin.
Negative_regulation (reduced) of Gene_expression (expression) of AQP6 mRNA associated with aspirin
1) Confidence 0.58 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2810475 Disease Relevance 0 Pain Relevance 0.05
In further support of this role, treating mice with salicylates, which impair OHC electromotility, dramatically reduced aquaporin-6 expression in the inner ear epithelia but not in control tissues, suggesting a role for this protein in modulating OHCs' responses.


1.

Negative_regulation (reduced) of Gene_expression (expression) of aquaporin-6 in inner ear
2) Confidence 0.43 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2810475 Disease Relevance 0 Pain Relevance 0
AQP6 mRNA expression and protein labeling of the organ of Corti are dramatically reduced already at 3 hrs after the last day of treatment with aspirin.
Negative_regulation (reduced) of Gene_expression (expression) of AQP6 mRNA associated with aspirin
3) Confidence 0.43 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2810475 Disease Relevance 0 Pain Relevance 0.05
Results showed that aspirin treatment significantly decreases AQP6 mRNA expression (about 70%, Figure 3), while no significant changes were observed for AQP1, 2, 4 and 7 transcripts under this condition.
Negative_regulation (decreases) of Gene_expression (expression) of AQP6 mRNA associated with aspirin
4) Confidence 0.43 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2810475 Disease Relevance 0 Pain Relevance 0.30

General Comments

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