INT29356

Context Info Confidence 0.67 First Reported 1986 Last Reported 2007 Negated 1 Speculated 0 Reported most in Abstract Documents 8 Total Number 8 Disease Relevance 0.22 Pain Relevance 3.49

cell differentiation (YY1) chromosome organization (YY1) RNA binding (YY1) plasma membrane (YY1) nucleus (YY1) intracellular (YY1)

Anatomy Link Frequency NK cell 2 YY1 (Homo sapiens)

Pain Link Frequency Relevance Heat opioid receptor 10 100.00 antagonist 6 100.00 Delta opioid receptors 4 100.00 opiate 5 99.96 Enkephalin 11 99.78 narcan 2 99.76 agonist 8 99.60 Opioid 9 98.64 alcohol 2 88.56 Potency 5 84.40

Disease Link Frequency Relevance Heat Stress 1 84.32 Alcohol Addiction 2 74.68 Pain 1 60.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results of these studies have allowed the identification of a low energy conformer common to all of these analogs which could be responsible for their high affinity delta-receptor binding.

Positive_regulation (responsible) of delta Binding (binding) of

1) Confidence 0.67 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2829004 Disease Relevance 0 Pain Relevance 0.17

Sodium ions increase the binding of the antagonist peptide ICI 174864 to the delta-opiate receptor.

Positive_regulation (increase) of delta Binding (binding) of associated with antagonist, narcan and opiate

2) Confidence 0.49 Published 1986 Journal Neuropeptides Section Title Doc Link 3010168 Disease Relevance 0.08 Pain Relevance 0.47

Here we report that endocytosis of mu and delta opioid receptors is not required for efficient ligand-induced activation of mitogen-activated protein kinase.

Neg (not) Positive_regulation (required) of delta Binding (endocytosis) of associated with delta opioid receptors

3) Confidence 0.49 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10455121 Disease Relevance 0 Pain Relevance 0.05

Replacement of Phe(3) by Dmp increased the affinity over 10-fold for both mu- and delta-opioid receptors, without affecting receptor selectivity.

Positive_regulation (increased) of delta Binding (affinity) of associated with delta opioid receptors

4) Confidence 0.49 Published 2003 Journal Bioorg. Med. Chem. Section Abstract Doc Link 12537996 Disease Relevance 0 Pain Relevance 0.12

Naltrexone disrupts this feedback control by reducing micro opioid receptor function, thereby up-regulating delta opioid receptor binding, which results in an enhanced NK cell cytolytic response to delta opioid receptor ligands.

Positive_regulation (up-regulating) of delta Binding (binding) of in NK cell associated with opioid receptor

5) Confidence 0.49 Published 2004 Journal J. Immunol. Section Abstract Doc Link 15210757 Disease Relevance 0.07 Pain Relevance 0.74

Staggered expression resulted in non-interacting mu and delta receptors, even though both receptors were colocalized at the cell surface.

Positive_regulation (resulted) of delta Binding (non-interacting) of

6) Confidence 0.49 Published 2007 Journal Biochemistry Section Abstract Doc Link 17941650 Disease Relevance 0 Pain Relevance 0.31

Structural requirements for delta opioid receptor binding.

Positive_regulation (requirements) of delta Binding (binding) of associated with enkephalin and opioid receptor

7) Confidence 0.45 Published 1987 Journal Mol. Pharmacol. Section Title Doc Link 3037296 Disease Relevance 0 Pain Relevance 0.79

Similarly, treatment with mu-selective ligands results in a significant increase in the binding of a delta receptor agonist.

Positive_regulation (increase) of delta Binding (binding) of associated with agonist

8) Confidence 0.45 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11069979 Disease Relevance 0.06 Pain Relevance 0.86

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