INT293580

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Context Info
Confidence 0.97
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.97
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Nmnat2) biosynthetic process (Nmnat2) nucleus (Nmnat2)
nucleotidyltransferase activity (Nmnat2) cytoplasm (Nmnat2)
Anatomy Link Frequency
neurites 1
Nmnat2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 10 5.00 Very Low Very Low Very Low
dorsal root ganglion 6 5.00 Very Low Very Low Very Low
induced neuropathy 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Sciatic nerve 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Wallerian Degeneration 174 99.84 Very High Very High Very High
Stress 6 91.24 High High
Injury 34 90.52 High High
Targeted Disruption 30 5.00 Very Low Very Low Very Low
Death 18 5.00 Very Low Very Low Very Low
Blister 6 5.00 Very Low Very Low Very Low
Ganglion Cysts 6 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low
Demyelinating Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, continued degradation of Nmnat2 in WldS neurites rules out an alternative hypothesis, that WldS could delay axon degeneration by stabilizing Nmnat2.
Protein_catabolism (degradation) of Nmnat2 in neurites associated with wallerian degeneration
1) Confidence 0.97 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.79 Pain Relevance 0
Proteasome inhibition modestly extends the latent phase of Wallerian degeneration in SCG explant cultures [18], so we tested whether this correlates with reduced turnover of endogenous Nmnat2 given that FLAG-tagged Nmnat2 is degraded via the proteasome in HEK cells (Figure 6B).
Protein_catabolism (degraded) of Nmnat2 associated with wallerian degeneration
2) Confidence 0.85 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.17 Pain Relevance 0

General Comments

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