INT293585

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Context Info
Confidence 0.75
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.74
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Nmnat1) nucleus (Nmnat1) nucleotidyltransferase activity (Nmnat1)
Anatomy Link Frequency
neurons 1
Nmnat1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 20 5.00 Very Low Very Low Very Low
dorsal root ganglion 12 5.00 Very Low Very Low Very Low
induced neuropathy 8 5.00 Very Low Very Low Very Low
Taxol 8 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
Sciatic nerve 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Wallerian Degeneration 348 99.24 Very High Very High Very High
Targeted Disruption 60 97.88 Very High Very High Very High
Injury 68 90.64 High High
Stress 12 64.84 Quite High
Death 36 33.68 Quite Low
Blister 12 5.00 Very Low Very Low Very Low
Ganglion Cysts 12 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Neuropathic Pain 8 5.00 Very Low Very Low Very Low
Demyelinating Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability of barely detectable extra-nuclear WldS to protect injured WldS mouse axons suggests that minimal mis-localization of relatively stable Nmnat1 and Nmnat3 may be sufficient to confer strong protection.
Localization (localization) of Nmnat1 associated with wallerian degeneration
1) Confidence 0.75 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.73 Pain Relevance 0
The absence of significant axon protection in transgenic mice expressing Nmnat1 in neurons at similar levels to WldS in WldS neurons [4],[8] suggests either that Nmnat1 localization is more rigorously controlled in vivo or that Nmnat1 overexpression is greater in vitro.
Localization (localization) of Nmnat1 in neurons associated with targeted disruption and wallerian degeneration
2) Confidence 0.65 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.76 Pain Relevance 0
The ability of exogenous nuclear Nmnat1 and mitochondrial Nmnat3 to confer axon protection in a number of situations outwardly seems to contradict the claim that Nmnat localization is actually important, but there is increasing evidence to support it.
Localization (localization) of Nmnat
3) Confidence 0.65 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.70 Pain Relevance 0
Moreover, although their predominant localizations are nuclear (Nmnat1), Golgi-associated (Nmnat2) and mitochondrial (Nmnat3) [34], the recent finding that WldS acts at a non-nuclear site despite its nuclear abundance [3] reminds us that low levels of protein can act elsewhere, especially if enzyme activity amplifies the effect.
Localization (localizations) of Nmnat1 associated with wallerian degeneration
4) Confidence 0.57 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.55 Pain Relevance 0

General Comments

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