INT293586

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.78
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Nmnat1) nucleus (Nmnat1) nucleotidyltransferase activity (Nmnat1)
Anatomy Link Frequency
neurons 2
neurites 1
Nmnat1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 20 5.00 Very Low Very Low Very Low
dorsal root ganglion 12 5.00 Very Low Very Low Very Low
induced neuropathy 8 5.00 Very Low Very Low Very Low
Taxol 8 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
Sciatic nerve 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 4 91.20 High High
Wallerian Degeneration 348 89.20 High High
Injury 68 83.16 Quite High
Death 36 81.44 Quite High
Targeted Disruption 60 69.08 Quite High
Stress 12 60.96 Quite High
Toxicity 4 49.88 Quite Low
Neurodegenerative Disease 4 25.00 Low Low
Blister 12 5.00 Very Low Very Low Very Low
Ganglion Cysts 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, endogenous Nmnat1 and Nmnat3 (which do appear to be expressed in SCG neurons; Figure S3) cannot compensate for loss of Nmnat2 (Figure 4), probably as a result of strict compartmentalization.
Nmnat1 Binding (endogenous) of in neurons
1) Confidence 0.35 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.68 Pain Relevance 0
Specific depletion of Nmnat2 is sufficient to induce Wallerian-like degeneration of uninjured axons which endogenous Nmnat1 and Nmnat3 cannot prevent.
Nmnat1 Binding (endogenous) of
2) Confidence 0.30 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2811159 Disease Relevance 0.17 Pain Relevance 0
Importantly, these data also indicate that endogenous Nmnat1 and Nmnat3 cannot compensate for loss of Nmnat2, despite the ability of these proteins to protect injured neurites when sufficiently overexpressed [1],[25].


Nmnat1 Binding (endogenous) of in neurites
3) Confidence 0.30 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.72 Pain Relevance 0
Primers used for detection of Nmnat isoform transcripts in SCG neuron RNA were as follows: Nmnat1 5?
Nmnat1 Binding (were) of in neuron
4) Confidence 0.30 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.20 Pain Relevance 0

General Comments

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