INT293599

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.02
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Nmnat2) biosynthetic process (Nmnat2) nucleus (Nmnat2)
nucleotidyltransferase activity (Nmnat2) cytoplasm (Nmnat2)
Anatomy Link Frequency
neurons 2
neurites 2
Nmnat2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 10 5.00 Very Low Very Low Very Low
dorsal root ganglion 6 5.00 Very Low Very Low Very Low
induced neuropathy 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Sciatic nerve 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 34 96.56 Very High Very High Very High
Wallerian Degeneration 174 80.48 Quite High
Stress 6 57.12 Quite High
Targeted Disruption 30 28.32 Quite Low
Death 18 5.00 Very Low Very Low Very Low
Blister 6 5.00 Very Low Very Low Very Low
Ganglion Cysts 6 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low
Demyelinating Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, loss of endogenous Nmnat2 occurs before cleavage of NF-H, which accompanies physical break-down of SCG neurites after injury [18] or protein synthesis suppression (Figure 1D), and before ?
Positive_regulation (occurs) of Negative_regulation (loss) of Nmnat2 in neurites associated with injury
1) Confidence 0.43 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.35 Pain Relevance 0
First, endogenous Nmnat1 and Nmnat3 (which do appear to be expressed in SCG neurons; Figure S3) cannot compensate for loss of Nmnat2 (Figure 4), probably as a result of strict compartmentalization.
Spec (probably) Positive_regulation (compensate) of Negative_regulation (loss) of Nmnat2 in neurons
2) Confidence 0.43 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.67 Pain Relevance 0

General Comments

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