INT293609

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.73
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurites 4
Wld (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 10 5.00 Very Low Very Low Very Low
dorsal root ganglion 6 5.00 Very Low Very Low Very Low
induced neuropathy 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Sciatic nerve 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Wallerian Degeneration 174 100.00 Very High Very High Very High
Injury 34 21.44 Low Low
Targeted Disruption 30 5.00 Very Low Very Low Very Low
Death 18 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Blister 6 5.00 Very Low Very Low Very Low
Ganglion Cysts 6 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low
Demyelinating Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, levels of WldS protein are only moderately reduced in neurites 48 h after transection (Figure S8).
Negative_regulation (reduced) of Gene_expression (levels) of WldS in neurites associated with wallerian degeneration
1) Confidence 0.41 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.83 Pain Relevance 0
The continued presence of WldS in transected WldS neurites long after Nmnat2 is lost shows that WldS does not act by stabilizing Nmnat2 but instead supports a model in which WldS substitutes for the functionally related Nmnat2.


Negative_regulation (lost) of Gene_expression (presence) of WldS in neurites associated with wallerian degeneration
2) Confidence 0.41 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.90 Pain Relevance 0

General Comments

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