INT293617

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Context Info
Confidence 0.65
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.90
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Nmnat2) biosynthetic process (Nmnat2) nucleus (Nmnat2)
nucleotidyltransferase activity (Nmnat2) cytoplasm (Nmnat2)
Anatomy Link Frequency
neurites 3
Wld (Mus musculus)
Nmnat2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 15 5.00 Very Low Very Low Very Low
dorsal root ganglion 9 5.00 Very Low Very Low Very Low
induced neuropathy 6 5.00 Very Low Very Low Very Low
Taxol 6 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
Sciatic nerve 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Wallerian Degeneration 261 100.00 Very High Very High Very High
Stress 9 88.00 High High
Injury 51 87.28 High High
Neurodegenerative Disease 3 34.16 Quite Low
Targeted Disruption 45 5.00 Very Low Very Low Very Low
Death 27 5.00 Very Low Very Low Very Low
Blister 9 5.00 Very Low Very Low Very Low
Ganglion Cysts 9 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nmnat2 turnover is equally rapid in injured WldS neurites, despite delayed neurite degeneration, showing it is not a consequence of degeneration and also that WldS does not stabilize Nmnat2.
WldS Neg (not) Positive_regulation (stabilize) of Nmnat2 in neurite
1) Confidence 0.65 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2811159 Disease Relevance 0.22 Pain Relevance 0
Importantly, continued degradation of Nmnat2 in WldS neurites rules out an alternative hypothesis, that WldS could delay axon degeneration by stabilizing Nmnat2.
WldS Positive_regulation (stabilizing) of Nmnat2 in neurites associated with wallerian degeneration
2) Confidence 0.65 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.80 Pain Relevance 0
The continued presence of WldS in transected WldS neurites long after Nmnat2 is lost shows that WldS does not act by stabilizing Nmnat2 but instead supports a model in which WldS substitutes for the functionally related Nmnat2.


WldS Positive_regulation (stabilizing) of Nmnat2 in neurites associated with wallerian degeneration
3) Confidence 0.50 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.88 Pain Relevance 0

General Comments

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