INT293677

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Context Info
Confidence 0.62
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.80
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RB1) DNA binding (RB1) nucleus (RB1)
molecular_function (RB1) cell division (RB1) cellular_component (RB1)
RB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 20 78.72 Quite High
Kinase C 35 74.28 Quite High
Inflammation 35 39.44 Quite Low
Inflammatory stimuli 5 28.84 Quite Low
cytokine 10 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Dismenorea 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asymptomatic Infections 45 93.68 High High
Infection 65 80.20 Quite High
Premature Birth 55 78.44 Quite High
INFLAMMATION 50 39.44 Quite Low
Pre-term Labor 10 5.00 Very Low Very Low Very Low
Dysmenorrhea 5 5.00 Very Low Very Low Very Low
Cerebral Palsy 5 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low
Syndrome 5 5.00 Very Low Very Low Very Low
Breast Cancer 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B activation led to an increase in PRA and PRB mRNA and protein expression.
Transcription (expression) of PRB
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.15 Pain Relevance 0
In order to simulate progesterone treatment we increased the PRB mRNA concentration 2, 5 and 10 fold above the baseline (0.04 ┬ÁM?
Transcription (concentration) of PRB
2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.40 Pain Relevance 0.03
B activation PRA protein increased 14 fold above baseline (Figure 1A and 1B); PRB mRNA and protein expression increased 4.2 fold (Figure 2A and 2B respectively).
Transcription (expression) of PRB
3) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.25 Pain Relevance 0
During pregnancy the transcriptional activity of PRB is higher than that of ER, and PRA transcription increases in association with the onset of labor [22], [24], [26].
Transcription (activity) of PRB
4) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0 Pain Relevance 0.03
In vitro studies indicate that PRA blocks progesterone action by inhibiting the transcriptional activity of PRB [20] and consequently suppresses progesterone responsiveness.
Transcription (activity) of PRB
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0 Pain Relevance 0.11

General Comments

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