INT293703

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.99 Pain Relevance 0.42

nucleolus (DDX41) RNA binding (DDX41) nucleus (DDX41) helicase activity (DDX41)

DDX41 (Homo sapiens) C21orf91 (Homo sapiens)

Pain Link Frequency Relevance Heat Arthritis 36 90.40 Inflammation 22 80.56 rheumatoid arthritis 30 56.56 Adalimumab 16 53.56 Infliximab 14 50.68 spinal inflammation 2 34.96 Crohn's disease 2 31.40 cytokine 8 11.88 antagonist 6 5.92 Etanercept 4 5.00

Disease Link Frequency Relevance Heat Arthritis 42 90.40 INFLAMMATION 18 80.56 Toxicity 2 69.44 Rheumatoid Arthritis 30 56.56 Disease 12 55.00 Inflammatory Bowel Disease 6 52.48 Low Back Pain 2 34.96 Seronegative Spondarthritis 2 33.60 Pressure And Volume Under Development 10 5.00 Immunization 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It was found that the epitope peptide YG1 could not be recognized by the marketed Abs, so it suggested that YG1 was a novel epitope of hTNF-?.

Abs Binding (recognized) of YG1

1) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811745 Disease Relevance 0.49 Pain Relevance 0.21

It was found that the epitope peptide YG1 could not be recognized by the marketed Abs, so it suggested that YG1 was a novel epitope of hTNF-?.

Abs Binding (recognized) of YG1

2) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811745 Disease Relevance 0.49 Pain Relevance 0.21

General Comments

This test has worked.