INT293704

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.01 Pain Relevance 0.61

helicase activity (DDX41) intracellular (TNF) extracellular matrix organization (TNF) extracellular space (TNF) signal transduction (TNF) extracellular region (TNF)

TNF (Homo sapiens) DDX41 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 15 94.48 Adalimumab 8 91.48 Infliximab 7 88.60 spinal inflammation 1 72.88 Arthritis 18 71.52 Inflammation 11 69.88 Crohn's disease 1 69.32 cytokine 4 49.80 antagonist 3 5.00 Etanercept 2 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 15 94.48 Disease 6 92.92 Inflammatory Bowel Disease 3 90.40 Low Back Pain 1 72.88 Seronegative Spondarthritis 1 71.52 INFLAMMATION 9 66.60 Arthritis 21 14.08 Pressure And Volume Under Development 5 5.00 Immunization 4 5.00 Erythema 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Those results suggested the two Abs would bind the different sites of TNF-?.

TNF Binding (bind) of Abs

1) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811745 Disease Relevance 1.01 Pain Relevance 0.61

General Comments

This test has worked.