INT293760

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.99
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCND3) nucleus (CCND3) cell division (CCND3)
cytoplasm (CCND3)
Anatomy Link Frequency
lung 1
CCND3 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 25 61.60 Quite High
Pain 5 31.20 Quite Low
antagonist 9 16.20 Low Low
aspirin 7 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 3 100.00 Very High Very High Very High
Hyperplasia 1 100.00 Very High Very High Very High
Prostate Cancer 135 99.80 Very High Very High Very High
Targeted Disruption 61 98.08 Very High Very High Very High
Lung Cancer 5 98.08 Very High Very High Very High
Carcinoma 1 67.84 Quite High
Breast Cancer 5 62.84 Quite High
Cancer 73 62.00 Quite High
Colon Cancer 3 61.84 Quite High
Malignant Neoplastic Disease 1 51.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then calculated the effect of these perturbation on cyclin D and PSA expression levels along with ERK and AR activation levels.
Regulation (effect) of cyclin D
1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.43 Pain Relevance 0
However, more importantly, ERK perturbations greatly effected cyclin D expression levels.
Regulation (effected) of cyclin D
2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.51 Pain Relevance 0
Thus, while the initiating events driving TOR activation were different, the subsequent up-regulation of cyclin D translation was similar.
Regulation (regulation) of cyclin D
3) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0
Many studies have identified a direct correlation between cyclin D regulation and prostate cancer, as well as breast and non-small cell lung cancer [71]–[73].
Regulation (regulation) of cyclin D in lung associated with lung cancer and prostate cancer
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.32 Pain Relevance 0
Our network model included: nuclear hormone and transmembrane growth factor receptor activation; transcriptional activity via the MAPK subsystem [28]–[30] together with outlaw activation of AR via MAPK [15], [18]; PI3K/AKT/TOR mediated translation initiation [31], [32]; the transcriptional and translational regulation of PSA, cyclin D and PAcP expression [14], [20]; and the regulation of Her2 activity by PAcP [26] (Fig. 1).
Regulation (regulation) of cyclin D
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.25 Pain Relevance 0.03
This complex regulates transcription of multiple genes involved in cellular proliferation, differentiation, survival and apoptosis, including c-myc and cyclin D [11,12].
Regulation (regulates) of cyclin D associated with apoptosis and hyperplasia
6) Confidence 0.01 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.49 Pain Relevance 0

General Comments

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