INT293761

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.85
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF4E) translation (EIF4E) cytoplasm (EIF4E)
EIF4E (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 15 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 3 99.72 Very High Very High Very High
Targeted Disruption 36 98.08 Very High Very High Very High
Prostate Cancer 81 91.28 High High
Cancer 36 72.80 Quite High
Lung Cancer 3 50.16 Quite High
Death 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Metastasis 3 5.00 Very Low Very Low Very Low
Hypersensitivity 3 5.00 Very Low Very Low Very Low
Shock 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduction of eIF4E resulted in a 89% loss of expression and, full knock-out simulations predicted a complete loss of cyclin D and PSA.


Negative_regulation (Reduction) of eIF4E associated with targeted disruption
1) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.49 Pain Relevance 0
Down-regulation of eIF4E resulted in decreased cyclin D expression and decreased growth rate without the deleterious effect of inhibitors such as rapamycin which act further upstream [68].
Negative_regulation (regulation) of eIF4E
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.32 Pain Relevance 0
Upregulated PI3K then drove Akt dependent activation of TOR which led to enhanced liberation of eIF4E from 4E-BP1.
Negative_regulation (liberation) of eIF4E
3) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.05 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox