INT293761

Context Info Confidence 0.17 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.85 Pain Relevance 0

cytosol (EIF4E) translation (EIF4E) cytoplasm (EIF4E)

EIF4E (Homo sapiens)

Pain Link Frequency Relevance Heat addiction 15 5.00 Pain 3 5.00 antagonist 3 5.00

Disease Link Frequency Relevance Heat Breast Cancer 3 99.72 Targeted Disruption 36 98.08 Prostate Cancer 81 91.28 Cancer 36 72.80 Lung Cancer 3 50.16 Death 6 5.00 Pain 3 5.00 Metastasis 3 5.00 Hypersensitivity 3 5.00 Shock 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Reduction of eIF4E resulted in a 89% loss of expression and, full knock-out simulations predicted a complete loss of cyclin D and PSA.

Negative_regulation (Reduction) of eIF4E associated with targeted disruption

1) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.49 Pain Relevance 0

Down-regulation of eIF4E resulted in decreased cyclin D expression and decreased growth rate without the deleterious effect of inhibitors such as rapamycin which act further upstream [68].

Negative_regulation (regulation) of eIF4E

2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.32 Pain Relevance 0

Upregulated PI3K then drove Akt dependent activation of TOR which led to enhanced liberation of eIF4E from 4E-BP1.

Negative_regulation (liberation) of eIF4E

3) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.05 Pain Relevance 0

General Comments

This test has worked.