INT293769

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.23
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCND3) nucleus (CCND3) cell division (CCND3)
cytoplasm (CCND3)
CCND3 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 10 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 2 93.94 High High
Hyperplasia 1 55.28 Quite High
Prostate Cancer 54 50.00 Quite Low
Cancer 49 48.80 Quite Low
Adenocarcinoma 1 15.04 Low Low
Disease 29 5.00 Very Low Very Low Very Low
Targeted Disruption 24 5.00 Very Low Very Low Very Low
Papillomavirus Infection 21 5.00 Very Low Very Low Very Low
Metastasis 14 5.00 Very Low Very Low Very Low
Toxicity 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the cyclin D increase is only notable in response to high levels of DHT (10 or 100nM) the prediction is qualitatively consistent with experimental data not included in the ensemble calculations [60].
Positive_regulation (increase) of cyclin D
1) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0
Furthermore, the model predicted a dose dependent increase in C-33 cyclin D levels 24 hours after addition of DHT (Fig. 6A).
Positive_regulation (increase) of cyclin D
2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0
Processes that are activated by EGFR stimulation include signal transduction pathways for PI3K-Akt (related to survival and apoptosis evasion) and Ras-Raf-MEK-MAPK (relating to proliferation).15 In addition, there is an interaction between EGFR expression and signal transducers and activators of transcription 3 (eg, STAT3), which play a role in the regulation of transcription of genes involved in cell cycle progression such as Fos, Cyclin-D, CDC25A, c-Myc and Pim1 and the upregulation of antiapoptotic genes such as BCL2.16,17
Positive_regulation (upregulation) of Cyclin-D associated with apoptosis
3) Confidence 0.03 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921255 Disease Relevance 0.23 Pain Relevance 0

General Comments

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