INT293769

Context Info Confidence 0.06 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.23 Pain Relevance 0

signal transduction (CCND3) nucleus (CCND3) cell division (CCND3) cytoplasm (CCND3)

CCND3 (Homo sapiens)

Pain Link Frequency Relevance Heat addiction 10 5.00 Pain 3 5.00 alcohol 2 5.00 antagonist 2 5.00 palliative 1 5.00 methotrexate 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 2 93.94 Hyperplasia 1 55.28 Prostate Cancer 54 50.00 Cancer 49 48.80 Adenocarcinoma 1 15.04 Disease 29 5.00 Targeted Disruption 24 5.00 Papillomavirus Infection 21 5.00 Metastasis 14 5.00 Toxicity 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although the cyclin D increase is only notable in response to high levels of DHT (10 or 100nM) the prediction is qualitatively consistent with experimental data not included in the ensemble calculations [60].

Positive_regulation (increase) of cyclin D

1) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0

Furthermore, the model predicted a dose dependent increase in C-33 cyclin D levels 24 hours after addition of DHT (Fig. 6A).

Positive_regulation (increase) of cyclin D

2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0

Processes that are activated by EGFR stimulation include signal transduction pathways for PI3K-Akt (related to survival and apoptosis evasion) and Ras-Raf-MEK-MAPK (relating to proliferation).15 In addition, there is an interaction between EGFR expression and signal transducers and activators of transcription 3 (eg, STAT3), which play a role in the regulation of transcription of genes involved in cell cycle progression such as Fos, Cyclin-D, CDC25A, c-Myc and Pim1 and the upregulation of antiapoptotic genes such as BCL2.16,17

Positive_regulation (upregulation) of Cyclin-D associated with apoptosis

3) Confidence 0.03 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921255 Disease Relevance 0.23 Pain Relevance 0

General Comments

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