INT293773

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 2.72
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCND3) nucleus (CCND3) cell division (CCND3)
cytoplasm (CCND3)
Anatomy Link Frequency
mammary glands 2
CCND3 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 45 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 132 99.84 Very High Very High Very High
Targeted Disruption 114 98.84 Very High Very High Very High
Lung Cancer 9 98.32 Very High Very High Very High
Prostate Cancer 243 96.32 Very High Very High Very High
Aging 5 90.84 High High
Disease 16 90.20 High High
Cancer 199 87.56 High High
Metastasis 19 62.52 Quite High
Recurrence 9 61.72 Quite High
Malignant Neoplastic Disease 6 18.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, MMTV-cyclin D2 mice show increased proliferation of mammary glands in pregnant females, but alveolar differentiation is partially or completely inhibited.157 In one report, cyclin D3 was overexpressed in breast cancers, but there are limited data on its relationship to the phenotype of breast cancer and prognosis of patients.158 Keyomarsi et al showed that the absence of cyclin D1 or cyclin D3 protein expression was associated with improved disease-specific and overall survival, but the correlations were less striking than those for cyclin E.159

Cyclin E

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of cyclin D3 in mammary glands associated with breast cancer and disease
1) Confidence 0.10 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.77 Pain Relevance 0
Balk et al. demonstrated that increased cyclin D expression in PTEN LNCaP cells following DHT addition was largely because of increased translation [74].
Positive_regulation (increased) of Gene_expression (expression) of cyclin D
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.25 Pain Relevance 0
In this study, we explored whether the MAPK and Akt signaling axes synergistically activated the expression of cyclin D.
Spec (whether) Positive_regulation (activated) of Gene_expression (expression) of cyclin D
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.38 Pain Relevance 0
Analysis of the ensemble of AI models suggested the Akt and MAPK pathways synergistically enhanced cyclin D expression by up-regulating translation.
Positive_regulation (enhanced) of Gene_expression (expression) of cyclin D
4) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.29 Pain Relevance 0
Knock-in simulations of eIF4E demonstrated an 8.7 and 5.2 fold increase in cyclin D and PSA expression.
Positive_regulation (increase) of Gene_expression (expression) of cyclin D associated with targeted disruption
5) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.59 Pain Relevance 0
Furthermore, the model predicted a dose dependent increase in C-33 cyclin D levels 24 hours after addition of DHT (Fig. 6A).
Positive_regulation (increase) of Gene_expression (levels) of cyclin D
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0
At steady-state, the MAPK and Akt pathways synergistically () activated cyclin D expression in C-81 cells without androgen (Fig. 9A).
Positive_regulation (activated) of Gene_expression (expression) of cyclin D
7) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.30 Pain Relevance 0
Cyclin D expression was coupled to ERK through the ETS and AP1 transcription factors, both of which activate cyclin D expression [59].
Positive_regulation (activate) of Gene_expression (expression) of cyclin D
8) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0
To address this, we inspected every model in the ensemble and found that each predicted an above-additive increase in cyclin D expression (data not shown).
Positive_regulation (increase) of Gene_expression (expression) of cyclin D
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.13 Pain Relevance 0
Cyclin D expression was coupled to ERK through the ETS and AP1 transcription factors, both of which activate cyclin D expression [59].
Positive_regulation (coupled) of Gene_expression (expression) of Cyclin D
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0

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