INT293773

Context Info Confidence 0.10 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 9 Total Number 10 Disease Relevance 2.72 Pain Relevance 0

signal transduction (CCND3) nucleus (CCND3) cell division (CCND3) cytoplasm (CCND3)

Anatomy Link Frequency mammary glands 2 CCND3 (Homo sapiens)

Pain Link Frequency Relevance Heat addiction 45 5.00 Pain 9 5.00 antagonist 9 5.00 Inflammation 5 5.00 palliative 1 5.00

Disease Link Frequency Relevance Heat Breast Cancer 132 99.84 Targeted Disruption 114 98.84 Lung Cancer 9 98.32 Prostate Cancer 243 96.32 Aging 5 90.84 Disease 16 90.20 Cancer 199 87.56 Metastasis 19 62.52 Recurrence 9 61.72 Malignant Neoplastic Disease 6 18.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, MMTV-cyclin D2 mice show increased proliferation of mammary glands in pregnant females, but alveolar differentiation is partially or completely inhibited.157 In one report, cyclin D3 was overexpressed in breast cancers, but there are limited data on its relationship to the phenotype of breast cancer and prognosis of patients.158 Keyomarsi et al showed that the absence of cyclin D1 or cyclin D3 protein expression was associated with improved disease-specific and overall survival, but the correlations were less striking than those for cyclin E.159 Cyclin E

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of cyclin D3 in mammary glands associated with breast cancer and disease

1) Confidence 0.10 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.77 Pain Relevance 0

Balk et al. demonstrated that increased cyclin D expression in PTEN LNCaP cells following DHT addition was largely because of increased translation [74].

Positive_regulation (increased) of Gene_expression (expression) of cyclin D

2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.25 Pain Relevance 0

In this study, we explored whether the MAPK and Akt signaling axes synergistically activated the expression of cyclin D.

Spec (whether) Positive_regulation (activated) of Gene_expression (expression) of cyclin D

3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.38 Pain Relevance 0

Analysis of the ensemble of AI models suggested the Akt and MAPK pathways synergistically enhanced cyclin D expression by up-regulating translation.

Positive_regulation (enhanced) of Gene_expression (expression) of cyclin D

4) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.29 Pain Relevance 0

Knock-in simulations of eIF4E demonstrated an 8.7 and 5.2 fold increase in cyclin D and PSA expression.

Positive_regulation (increase) of Gene_expression (expression) of cyclin D associated with targeted disruption

5) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.59 Pain Relevance 0

Furthermore, the model predicted a dose dependent increase in C-33 cyclin D levels 24 hours after addition of DHT (Fig. 6A).

Positive_regulation (increase) of Gene_expression (levels) of cyclin D

6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0

At steady-state, the MAPK and Akt pathways synergistically () activated cyclin D expression in C-81 cells without androgen (Fig. 9A).

Positive_regulation (activated) of Gene_expression (expression) of cyclin D

7) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.30 Pain Relevance 0

Cyclin D expression was coupled to ERK through the ETS and AP1 transcription factors, both of which activate cyclin D expression [59].

Positive_regulation (activate) of Gene_expression (expression) of cyclin D

8) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0

To address this, we inspected every model in the ensemble and found that each predicted an above-additive increase in cyclin D expression (data not shown).

Positive_regulation (increase) of Gene_expression (expression) of cyclin D

9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.13 Pain Relevance 0

Cyclin D expression was coupled to ERK through the ETS and AP1 transcription factors, both of which activate cyclin D expression [59].

Positive_regulation (coupled) of Gene_expression (expression) of Cyclin D

10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.