INT293778

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.42
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF4E) translation (EIF4E) cytoplasm (EIF4E)
EIF4E (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 5 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 4 82.36 Quite High
Renal Cell Carcinoma 29 81.20 Quite High
Targeted Disruption 12 66.88 Quite High
Death 4 56.24 Quite High
Prostate Cancer 27 50.00 Quite Low
Metastasis 8 46.48 Quite Low
Cancer 32 40.24 Quite Low
Pneumonia 16 5.00 Very Low Very Low Very Low
Disease 13 5.00 Very Low Very Low Very Low
Toxicity 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The everolimus-FKBP12 complex binds to mTOR and reduces the activity of the downstream effectors S6 ribosomal protein kinase (S6K1) and translational repressor protein eukaryotic elongation factor 4E-binding protein (4EBP).19 eIF-4F activation results in the translation of a subset of capped mRNA containing highly structured 5?
Positive_regulation (activation) of eIF-4F
1) Confidence 0.45 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.22 Pain Relevance 0
Additionally, both mechanisms for the phosphorylation of 4E-BP1 by TOR kinase, a key step in translation initiation that liberates eIF4E, were also more importance in C-81.
Positive_regulation (liberates) of eIF4E
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.20 Pain Relevance 0

General Comments

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