INT293783

Context Info Confidence 0.07 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 1.45 Pain Relevance 0.06

signal transduction (CCND3) nucleus (CCND3) cell division (CCND3) cytoplasm (CCND3)

CCND3 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 4 57.52 addiction 20 48.84 antagonist 4 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 48 98.96 Prostate Cancer 108 88.24 Cancer 48 73.56 Pain 4 57.52 Breast Cancer 4 30.96 Death 8 5.00 Metastasis 4 5.00 Lung Cancer 4 5.00 Hypersensitivity 4 5.00 Shock 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Constitutive and regulated expression of PSA, cyclin D and the two forms of PAcP were considered in the model.

Regulation (regulated) of Gene_expression (expression) of cyclin D

1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.13 Pain Relevance 0.06

However, more importantly, ERK perturbations greatly effected cyclin D expression levels.

Regulation (effected) of Gene_expression (expression) of cyclin D

2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.52 Pain Relevance 0

We then calculated the effect of these perturbation on cyclin D and PSA expression levels along with ERK and AR activation levels.

Regulation (effect) of Gene_expression (expression) of cyclin D

3) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.43 Pain Relevance 0

Additionally, we observed that perturbations in Raf, MEK and ERK had a similar effect on cyclin D but not PSA expression, with ERK being more pronounced.

Regulation (effect) of Gene_expression (expression) of cyclin D

4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.37 Pain Relevance 0

General Comments

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