INT293783

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.45
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCND3) nucleus (CCND3) cell division (CCND3)
cytoplasm (CCND3)
CCND3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 57.52 Quite High
addiction 20 48.84 Quite Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 48 98.96 Very High Very High Very High
Prostate Cancer 108 88.24 High High
Cancer 48 73.56 Quite High
Pain 4 57.52 Quite High
Breast Cancer 4 30.96 Quite Low
Death 8 5.00 Very Low Very Low Very Low
Metastasis 4 5.00 Very Low Very Low Very Low
Lung Cancer 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Constitutive and regulated expression of PSA, cyclin D and the two forms of PAcP were considered in the model.
Regulation (regulated) of Gene_expression (expression) of cyclin D
1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.13 Pain Relevance 0.06
However, more importantly, ERK perturbations greatly effected cyclin D expression levels.
Regulation (effected) of Gene_expression (expression) of cyclin D
2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.52 Pain Relevance 0
We then calculated the effect of these perturbation on cyclin D and PSA expression levels along with ERK and AR activation levels.
Regulation (effect) of Gene_expression (expression) of cyclin D
3) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.43 Pain Relevance 0
Additionally, we observed that perturbations in Raf, MEK and ERK had a similar effect on cyclin D but not PSA expression, with ERK being more pronounced.
Regulation (effect) of Gene_expression (expression) of cyclin D
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.37 Pain Relevance 0

General Comments

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