INT293811

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.32
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (EIF4E, CCND3) cytosol (EIF4E) signal transduction (CCND3)
nucleus (CCND3) translation (EIF4E) cell division (CCND3)
EIF4E (Homo sapiens)
CCND3 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 5 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 1 99.72 Very High Very High Very High
Prostate Cancer 27 91.28 High High
Cancer 12 36.60 Quite Low
Lung Cancer 1 25.76 Quite Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Metastasis 1 5.00 Very Low Very Low Very Low
Hypersensitivity 1 5.00 Very Low Very Low Very Low
Shock 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Down-regulation of eIF4E resulted in decreased cyclin D expression and decreased growth rate without the deleterious effect of inhibitors such as rapamycin which act further upstream [68].
Negative_regulation (regulation) of eIF4E Negative_regulation (decreased) of Gene_expression (expression) of cyclin D
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.32 Pain Relevance 0

General Comments

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