INT293874

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.00
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
proximal 1
OCM (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 36 50.00 Quite Low
Earache 3 40.84 Quite Low
cytokine 15 5.00 Very Low Very Low Very Low
Inflammatory mediators 12 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 123 99.02 Very High Very High Very High
Respiratory Syncytial Virus 57 92.56 High High
Disease 63 91.60 High High
Deafness 9 87.80 High High
Influenza Virus Infection 69 82.76 Quite High
Bacterial Meningitis 9 78.72 Quite High
Emergencies 3 76.16 Quite High
Sprains And Strains 12 74.52 Quite High
Viral Infection 60 68.00 Quite High
Otitis 6 67.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RSV and perhaps other URT virus-mediated dysregulation of expression of effectors of innate immunity at the proximal or nasopharyngeal orifice of the Eustachian tube could thus contribute to weakening the effectiveness of this primary defense organ of the middle ear, thereby promoting retrograde movement of bacteria resident within the NP into the middle-ear space wherein OM is induced.


Positive_regulation (induced) of OM in proximal associated with respiratory syncytial virus
1) Confidence 0.05 Published 2010 Journal J Leukoc Biol Section Body Doc Link PMC2812561 Disease Relevance 0.16 Pain Relevance 0
Despite its prevalence, classically virulent microbes do not cause OM.
Neg (not) Positive_regulation (cause) of OM
2) Confidence 0.04 Published 2010 Journal J Leukoc Biol Section Body Doc Link PMC2812561 Disease Relevance 0.69 Pain Relevance 0
Even in the absence of a concurrent viral URT infection, children are colonized with the organisms that induce OM soon after birth.
Positive_regulation (induce) of OM associated with infection
3) Confidence 0.03 Published 2010 Journal J Leukoc Biol Section Body Doc Link PMC2812561 Disease Relevance 1.14 Pain Relevance 0

General Comments

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