INT293904

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Context Info
Confidence 0.54
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.19
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TPH2) small molecule metabolic process (TPH2) cellular nitrogen compound metabolic process (TPH2)
response to stress (TPH2)
Anatomy Link Frequency
brain 2
TPH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
drug abuse 28 99.84 Very High Very High Very High
depression 23 95.44 Very High Very High Very High
antidepressant 3 86.04 High High
positron emission tomography 19 81.04 Quite High
amygdala 28 77.20 Quite High
imagery 11 73.04 Quite High
agonist 3 67.32 Quite High
Central nervous system 16 57.72 Quite High
Serotonin 12 50.00 Quite Low
Tetrahydrobiopterin 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Dependence 28 99.84 Very High Very High Very High
Genetic Predisposition To Disease 3 97.68 Very High Very High Very High
Disease 18 97.52 Very High Very High Very High
Aggression 68 96.80 Very High Very High Very High
Depression 23 95.44 Very High Very High Very High
Suicidal Behaviour 46 95.32 Very High Very High Very High
Schizophrenia 18 89.12 High High
Stress 3 83.76 Quite High
Cognitive Disorder 3 74.80 Quite High
Attention Deficit Hyperactivity Disorder 15 52.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, dysregulations in TPH2 editing could be involved in the pathogenesis of psychiatric diseases or may directly result from substance abuse.
Regulation (dysregulations) of TPH2 associated with drug abuse and disease
1) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0.69 Pain Relevance 0.22
Thus, while we still have to elucidate the underlying mechanism of how rs4290270 A affects TPH2 alternative splicing and editing, the data demonstrate a genetic predisposition of homozygous A-allele carriers for suicide.


Regulation (affects) of TPH2 associated with suicidal behaviour and genetic predisposition to disease
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0.63 Pain Relevance 0.09
In order to control for the influence of these TPH2 polymorphisms on brain 5-HT synthesis when comparing the high and low physical aggression groups, differences in genotype distribution for each of these TPH2 variants between the trajectories were investigated.
Regulation (influence) of TPH2 in brain associated with aggression
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889822 Disease Relevance 0.36 Pain Relevance 0.21
Our findings suggest that brain 5-HT biosynthesis is also regulated by TPH2 pre-mRNA editing, which could be affected by drug abuse and environmental factors in analogy to the 5-HT2C receptor.
Regulation (affected) of TPH2 in brain associated with drug abuse
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0.52 Pain Relevance 0.13

General Comments

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