INT293912

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.20
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (UPF1) RNA binding (UPF1) helicase activity (UPF1)
cell cycle (UPF1) DNA binding (UPF1) cytoplasm (UPF1)
Anatomy Link Frequency
cleavage 1
UPF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
amygdala 9 92.24 High High
Tetrahydrobiopterin 8 40.52 Quite Low
Central nervous system 5 14.80 Low Low
drug abuse 8 5.00 Very Low Very Low Very Low
depression 7 5.00 Very Low Very Low Very Low
adenocard 5 5.00 Very Low Very Low Very Low
addiction 5 5.00 Very Low Very Low Very Low
melanocortin 1 receptor 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Dysautonomia 242 99.36 Very High Very High Very High
Contagious Ecthyma 8 89.60 High High
Disease 29 60.44 Quite High
Neurological Disease 3 45.92 Quite Low
Suicidal Behaviour 15 5.00 Very Low Very Low Very Low
Drug Dependence 8 5.00 Very Low Very Low Very Low
Depression 7 5.00 Very Low Very Low Very Low
Schizophrenia 6 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Rare Diseases 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although TPH2b 1 transcripts would be expected for degradation by NMD [40], [41], we detected them easily (Figure 1D).
Protein_catabolism (degradation) of transcripts
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0 Pain Relevance 0.05
Therefore, potential transcripts that are not cleaved and readthrough the JUNB poly(A) site are stabilised by cleavage and polyadenylation at the MC4R P2 site and can easily be detected using the composite RP probe described in Figure 4.
Protein_catabolism (cleaved) of transcripts in cleavage
2) Confidence 0.01 Published 2010 Journal EMBO J Section Body Doc Link PMC2876958 Disease Relevance 0.09 Pain Relevance 0
exon 36 inclusion ratio decreases when NMD pathway is inhibited (Figure S2), suggesting that transcripts including exon 36 are degraded through NMD in FD, as well as in control OE-MSCs (data not shown).


Protein_catabolism (degraded) of transcripts associated with familial dysautonomia
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.53 Pain Relevance 0
Such a difference is most likely explained by an extensive degradation of MU transcripts through the NMD pathway (Figure 2D), as was previously suggested [35].
Protein_catabolism (degradation) of transcripts
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.58 Pain Relevance 0

General Comments

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