INT29393

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Context Info
Confidence 0.67
First Reported 1980
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 5.28
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APRT) small molecule metabolic process (APRT) transferase activity, transferring glycosyl groups (APRT)
nucleolus (APRT) nucleus (APRT) cytoplasm (APRT)
Anatomy Link Frequency
muscle 1
neurons 1
APRT (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 49 99.52 Very High Very High Very High
noradrenaline 3 99.28 Very High Very High Very High
ischemia 8 99.06 Very High Very High Very High
Codeine 4 97.14 Very High Very High Very High
withdrawal 5 96.72 Very High Very High Very High
Nerve growth factor 5 95.60 Very High Very High Very High
opiate 1 92.72 High High
Enkephalin 10 90.48 High High
tolerance 11 88.40 High High
opioid receptor 2 87.36 High High
Disease Link Frequency Relevance Heat
Overdose 1 99.88 Very High Very High Very High
Shock 9 99.38 Very High Very High Very High
Cv Unclassified Under Development 9 99.06 Very High Very High Very High
Hypoxia 14 98.86 Very High Very High Very High
Neuroblastoma 3 97.52 Very High Very High Very High
Stress 41 97.36 Very High Very High Very High
Hyperostosis 3 87.40 High High
Cancer 269 87.08 High High
INFLAMMATION 39 86.32 High High
Diabetes Mellitus 14 85.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was found that the ACTH, cortisol (corticosterone), c-AMP were elevated during abstinence and these compounds were reduced after AES treatment.
Positive_regulation (elevated) of AMP
1) Confidence 0.67 Published 1980 Journal Am. J. Chin. Med. Section Abstract Doc Link 6113757 Disease Relevance 0.07 Pain Relevance 0.27
The Ellsworth-Howard test was performed on three patients; all had a normal phosphaturic response and an increase in urinary c'AMP to exogenous PTH.
Positive_regulation (increase) of AMP
2) Confidence 0.67 Published 1981 Journal J. Pediatr. Section Abstract Doc Link 6273518 Disease Relevance 0.49 Pain Relevance 0.08
Because of its positive inotropic effects that are independent of cyclic AMP, insulin was compared to epinephrine and glucagon as a novel treatment for cardiac toxicity from verapamil.
Neg (independent) Positive_regulation (independent) of AMP associated with cv unclassified under development
3) Confidence 0.49 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8246150 Disease Relevance 0.24 Pain Relevance 0
The differentiated cells had a relatively high activity of adenylate cyclase and cyclic AMP phosphodiesterase, and a high intracellular level of cyclic AMP. 3.
Positive_regulation (activity) of AMP
4) Confidence 0.45 Published 1987 Journal Int. J. Biochem. Section Abstract Doc Link 2830153 Disease Relevance 0.28 Pain Relevance 0.45
After pindolol noradrenaline concentration, DBH-activity, and c-AMP concentration were no longer increased during oral surgery.
Neg (no) Positive_regulation (increased) of AMP associated with noradrenaline
5) Confidence 0.45 Published 1981 Journal Arzneimittelforschung Section Abstract Doc Link 6119097 Disease Relevance 0.48 Pain Relevance 0.26
Patients present low or undetectable HPRT activity in haemolysates, with increased adenine phosphoribosyltransferase (APRT) activity.
Positive_regulation (increased) of APRT
6) Confidence 0.36 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2234399 Disease Relevance 0.07 Pain Relevance 0
Patients present low or undetectable HPRT activity in haemolysates, with increased adenine phosphoribosyltransferase (APRT) activity.
Positive_regulation (increased) of adenine phosphoribosyltransferase
7) Confidence 0.36 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2234399 Disease Relevance 0.07 Pain Relevance 0
Elevated APRT activity may also contribute to purine overproduction.


Positive_regulation (Elevated) of APRT
8) Confidence 0.24 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2234399 Disease Relevance 0.12 Pain Relevance 0.09
This near immediate activation of carbohydrate oxidation after the onset of exercise [37] is caused by the production of AMP, the increases in intramuscular free calcium and inorganic phosphate (both increase the rate of the phosphorylase reaction as calcium is an activator of phosphorylate and inorganic phosphate is a substrate), and the near spontaneous increase in blood glucose uptake into muscle caused by muscle contraction.
Positive_regulation (increases) of AMP in muscle
9) Confidence 0.07 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3005844 Disease Relevance 0 Pain Relevance 0
The concomitant chronic administration of codeine and glutethimide resulted in a pronounced and long-lasting energetic depletion of the neurons, consistent with the high risk of overdose, and increase of cAMP's stable metabolite, 5'-AMP.
Positive_regulation (increase) of AMP in neurons associated with overdose and codeine
10) Confidence 0.05 Published 2001 Journal J. Cell. Mol. Med. Section Abstract Doc Link 12067475 Disease Relevance 0.19 Pain Relevance 0.51
Finally, reduced ammonia production by AMP deaminase may have also reflected the activation of alternative routes of AMP metabolism, including 5'nucleotidase.
Positive_regulation (activation) of AMP
11) Confidence 0.03 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1187899 Disease Relevance 0.13 Pain Relevance 0
Significantly elevated AMP abundance was observed in HTLV1 and Tax1 transformed cells.
Positive_regulation (elevated) of AMP
12) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.43 Pain Relevance 0.08
The cause of elevated AMP levels in HTLV1 and Tax1transformed cells requires further investigation.
Positive_regulation (elevated) of AMP
13) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.28 Pain Relevance 0.06
CEM cells, whereas the levels of creatine, arginine, dopamine, homovanillic acid and AMP were upregulated.
Positive_regulation (upregulated) of AMP associated with dopamine
14) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0.12
AMPK is activated under conditions that deplete cellular ATP and elevate AMP levels such as glucose deprivation, hypoxia, ischemia, and heat shock, which are associated with an increased AMP/ATP ratio [268].
Positive_regulation (increased) of AMP associated with hypoxia, ischemia and shock
15) Confidence 0.02 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 1.19 Pain Relevance 0.10
AMPK is activated under conditions that deplete cellular ATP and elevate AMP levels such as glucose deprivation, hypoxia, ischemia, and heat shock, which are associated with an increased AMP/ATP ratio [268].
Positive_regulation (elevate) of AMP associated with hypoxia, ischemia and shock
16) Confidence 0.02 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 1.19 Pain Relevance 0.11
Hence, addition of ethanol is expected to stabilize adenine in pyrite suspensions.
Positive_regulation (stabilize) of adenine
17) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0.05 Pain Relevance 0
The addition of either catalase (reacts with H2O2 to form H2O and O2) or ethanol (┬ĽOH scavenger) to adenine/pyrite suspensions resulted in a stabilization of the adenine.
Positive_regulation (stabilization) of adenine
18) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0

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