INT29394

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Context Info
Confidence 0.77
First Reported 1983
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 3.62
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra1a) aging (Adra1a) plasma membrane (Adra1a)
response to stress (Adra1a) signal transducer activity (Adra1a)
Anatomy Link Frequency
outflow 1
thyroid 1
ureter 1
spinal cord 1
urethra 1
Adra1a (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 11 100.00 Very High Very High Very High
Pain 7 100.00 Very High Very High Very High
Neuropathic pain 2 99.60 Very High Very High Very High
addiction 1 99.02 Very High Very High Very High
reflex sympathetic dystrophy 3 98.60 Very High Very High Very High
antagonist 9 98.52 Very High Very High Very High
cINOD 1 98.28 Very High Very High Very High
diabetic neuropathy 3 97.24 Very High Very High Very High
Immobilon 2 96.72 Very High Very High Very High
central pain 1 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 4 99.60 Very High Very High Very High
Psychosis 1 99.46 Very High Very High Very High
Stress Incontinence 7 98.76 Very High Very High Very High
Complex Regional Pain Syndromes 3 98.28 Very High Very High Very High
INFLAMMATION 2 98.04 Very High Very High Very High
Diabetes Mellitus 3 97.24 Very High Very High Very High
Benign Prostatic Hypertrophy 5 95.80 Very High Very High Very High
Pain 7 95.28 Very High Very High Very High
Frailty 3 94.40 High High
Muscular Spasm 1 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alpha 1-adrenoceptor production of inositol phosphates mediates the inhibition of thyroxine release from the mouse thyroid.
Gene_expression (production) of Alpha 1-adrenoceptor in thyroid
1) Confidence 0.77 Published 1987 Journal J. Endocrinol. Section Title Doc Link 2830361 Disease Relevance 0 Pain Relevance 0.31
These results suggest that alpha1b-adrenergic receptors may be important therapeutic pharmacological targets not only in addiction but also in psychosis because most neuroleptics possess anti-alpha1-adrenergic properties.
Gene_expression (possess) of anti-alpha1-adrenergic associated with addiction and psychosis
2) Confidence 0.66 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12417637 Disease Relevance 0.16 Pain Relevance 0.60
Regional distribution of alpha-adrenoceptor subtypes in the female rabbit urethra.
Gene_expression (distribution) of alpha-adrenoceptor in urethra associated with stress incontinence
3) Confidence 0.64 Published 1986 Journal Acta Physiol. Scand. Section Title Doc Link 2869644 Disease Relevance 0.48 Pain Relevance 0.22
In summary alpha1-adrenoceptor blockers produce significant improvements in symptoms and flow rates in patients with bladder outflow obstruction due to benign prostatic hyperplasia.
Gene_expression (produce) of alpha1-adrenoceptor in outflow associated with benign prostatic hypertrophy
4) Confidence 0.52 Published 1999 Journal Eur. Urol. Section Abstract Doc Link 10393473 Disease Relevance 0.64 Pain Relevance 0.11
Alpha-1 adrenoceptor hyperresponsiveness in three neuropathic pain states: complex regional pain syndrome 1, diabetic peripheral neuropathic pain and central pain states following spinal cord injury.
Gene_expression (hyperresponsiveness) of Alpha-1 adrenoceptor in spinal cord associated with complex regional pain syndromes, pain, central pain, reflex sympathetic dystrophy, diabetic neuropathy, neuropathic pain and spinal cord
5) Confidence 0.37 Published 2004 Journal Pain Res Manag Section Title Doc Link 15211988 Disease Relevance 1.64 Pain Relevance 1.25
Alpha-adrenergic receptor can be found in the lower part of ureter as well.
Gene_expression (found) of Alpha-adrenergic receptor in ureter
6) Confidence 0.30 Published 2007 Journal Neurochem. Int. Section Abstract Doc Link 17688972 Disease Relevance 0.69 Pain Relevance 0.14
The relatively selective alpha-1 adrenoceptor agonist, cirazoline, given in doses up to 20 mg/kg i.m., produced in chicks behavioral manifestations suggestive of enhanced arousal.
Gene_expression (produced) of alpha-1 adrenoceptor associated with agonist
7) Confidence 0.12 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6138427 Disease Relevance 0 Pain Relevance 0.53
RT-PCR showed that the alpha1A-adrenoceptor was the sole alpha1-adrenoceptor subtype expressed in L6 cells.
Gene_expression (expressed) of alpha1A-adrenoceptor
8) Confidence 0.02 Published 2005 Journal Endocrinology Section Abstract Doc Link 15550506 Disease Relevance 0 Pain Relevance 0.38
RT-PCR showed that the alpha1A-adrenoceptor was the sole alpha1-adrenoceptor subtype expressed in L6 cells.
Gene_expression (expressed) of alpha1-adrenoceptor
9) Confidence 0.02 Published 2005 Journal Endocrinology Section Abstract Doc Link 15550506 Disease Relevance 0 Pain Relevance 0.37

General Comments

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