INT293973

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.80
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (POMC, Mc1r) small molecule metabolic process (POMC) signal transducer activity (Mc1r)
cell-cell signaling (POMC) cytoplasm (POMC) pigmentation (Mc1r)
Anatomy Link Frequency
T cells 1
POMC (Homo sapiens)
Mc1r (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 33 77.04 Quite High
Neuropeptide 12 50.00 Quite Low
Arthritis 3 21.48 Low Low
tolerance 3 11.32 Low Low
melanocortin 1 receptor 15 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 48 97.20 Very High Very High Very High
Targeted Disruption 6 93.44 High High
Skin Cancer 156 90.32 High High
Cancer 138 86.64 High High
Colitis 6 81.68 Quite High
INFLAMMATION 36 77.04 Quite High
Disease Progression 6 75.52 Quite High
Pressure And Volume Under Development 9 60.88 Quite High
Spontaneous Remission 3 58.64 Quite High
Adhesions 3 48.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-MSH via binding to MC-R is able to modulate the function of antigen-presenting cells [3], [4], [6].
MSH Binding (binding) of MC-R
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 0.99 Pain Relevance 0
-MSH might directly affect the phenotype or function of CD8+ T cells by binding to MC-1R.
MSH Spec (might) Binding (binding) of MC-1R in T cells
2) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 0.51 Pain Relevance 0
-MSH are predominantly mediated through binding to MC-1R [9], [16], [23], [54].
MSH Binding (binding) of MC-1R
3) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 0.30 Pain Relevance 0.07

General Comments

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