INT29402

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Context Info
Confidence 0.74
First Reported 1987
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 4.57
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Src) enzyme binding (Src) response to stress (Src)
cytoplasm (Src) cytosol (Src) cell proliferation (Src)
Anatomy Link Frequency
neurons 2
CNS 1
embryonic kidney 1
Src (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 16 99.94 Very High Very High Very High
5HT 90 99.08 Very High Very High Very High
qutenza 5 98.64 Very High Very High Very High
GABAergic 3 93.68 High High
Arthritis 20 92.40 High High
tetrodotoxin 5 92.12 High High
Root ganglion neuron 1 91.20 High High
fibrosis 9 83.12 Quite High
Inflammation 83 79.68 Quite High
dopamine receptor 3 78.88 Quite High
Disease Link Frequency Relevance Heat
Myeloid Leukemia 2 99.68 Very High Very High Very High
Chronic Myeloid Leukemia 2 99.58 Very High Very High Very High
Hyperplasia 9 99.08 Very High Very High Very High
Shock 4 92.64 High High
Arthritis 20 92.40 High High
Ganglion Cysts 1 90.88 High High
Injury 18 88.96 High High
Pressure And Volume Under Development 22 88.84 High High
Necrosis 10 88.40 High High
Systemic Sclerosis 60 88.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
But Src is highly expressed in fully differentiated neurons in the developed CNS, implying additional functions of this kinase.
Gene_expression (expressed) of Src in CNS associated with central nervous system
1) Confidence 0.74 Published 2004 Journal Oncogene Section Abstract Doc Link 15489918 Disease Relevance 0 Pain Relevance 0.27
In the central nervous system (CNS), Src and other Src family kinases are widely expressed and are abundant in neurons.
Gene_expression (expressed) of Src in neurons associated with central nervous system
2) Confidence 0.74 Published 2004 Journal Oncogene Section Abstract Doc Link 15489918 Disease Relevance 0 Pain Relevance 0.25
In the central nervous system (CNS), Src and other Src family kinases are widely expressed and are abundant in neurons.
Gene_expression (expressed) of Src in neurons associated with central nervous system
3) Confidence 0.74 Published 2004 Journal Oncogene Section Abstract Doc Link 15489918 Disease Relevance 0 Pain Relevance 0.25
However, the expression of other genes such as epidermal growth factor-receptor, glial fibrillary acidic protein, and several proto-oncogenes (src, fos and myc), and a cholinergic marker such as choline acetyltransferase activity were unaltered.
Gene_expression (expression) of src
4) Confidence 0.56 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7854069 Disease Relevance 0 Pain Relevance 0.20
Therefore, we conclude that PLC activation occurs concomitantly with pp60v-src expression, and hypothesize that pp60v-src-related membrane depolarization is the causal link between pp60v-src tyrosine kinase activity and stimulation of polyphosphoinositide metabolism.
Gene_expression (expression) of pp60v-src
5) Confidence 0.48 Published 1987 Journal Oncogene Section Abstract Doc Link 2830581 Disease Relevance 0.32 Pain Relevance 0.09
Prominent JGA hyperplasia was found to be present in 2/17 (12%) of our SRC cases [13].
Gene_expression (cases) of SRC associated with hyperplasia
6) Confidence 0.48 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2958499 Disease Relevance 1.52 Pain Relevance 0.11
Interestingly, they also found that, in the absence of SRC, a significant increase in arterial fibrointimal thickness was observed in dcSSc patients, and to a lesser extent in lcSSc patients, compared to controls.
Neg (absence) Gene_expression (absence) of SRC
7) Confidence 0.48 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2958499 Disease Relevance 0.80 Pain Relevance 0.08
We have previously demonstrated that both Src kinase and PLC?
Gene_expression (kinase) of Src
8) Confidence 0.38 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0
receptor (Epitomics, California, USA), Abelson kinase (Sigma), Src (Cell Signaling, Danvers, MDA) and phospho-Y416 and Y527 Src (Biosource, Carlsbad, CA), and phospho-tyrosine antibody (Santa Cruz, La Jolla, CA), and PLC?
Gene_expression (kinase) of Src
9) Confidence 0.38 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.03
Src-kinase as well as transfection of cells with short interference RNA (siRNA)
Gene_expression (transfection) of Src
10) Confidence 0.17 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 0.47 Pain Relevance 0.03
Compound 23, a close structural analog of dasatinib (BMS-354825), a marketed kinase inhibitor drug for the treatment of chronic myelogenous leukemia (CML), is a potent, selective, and ATP-competitive inhibitor of Lck and other Src family kinases (IC50?
Gene_expression (selective) of Src associated with myeloid leukemia and chronic myeloid leukemia
11) Confidence 0.14 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.65 Pain Relevance 0.08
Compound 23, a close structural analog of dasatinib (BMS-354825), a marketed kinase inhibitor drug for the treatment of chronic myelogenous leukemia (CML), is a potent, selective, and ATP-competitive inhibitor of Lck and other Src family kinases (IC50?
Gene_expression (other) of Src associated with myeloid leukemia and chronic myeloid leukemia
12) Confidence 0.14 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.64 Pain Relevance 0.08
The availability of these synthetic EETs has made it possible to evaluate another regioisomer, 14,15-EET. 14,15-EET was shown to induce angiogenesis via several pathways including: Src, phospatidylinositol-3-kinase/Akt (PI3K/Akt) signaling in parallel with mTOR-S6K1 activation and Src-dependent STAT-3-mediated VEGF expression [108, 109].
Gene_expression (expression) of Src-dependent
13) Confidence 0.10 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 0.09 Pain Relevance 0
m, 3 min) in the absence or presence of the Src kinase inhibitor PP2 or its inactive homolog PP3 (both 10 ?
Gene_expression (kinase) of Src
14) Confidence 0.09 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427346 Disease Relevance 0 Pain Relevance 0.21
m, 3 min) in the absence or presence of the Src kinase inhibitor PP2 or its inactive homolog PP3 (both 10 ?
Neg (absence) Gene_expression (absence) of Src
15) Confidence 0.09 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427346 Disease Relevance 0 Pain Relevance 0.21
PP2 also abolished currents in human embryonic kidney-293 cells transfected with rat TRPV1, whereas cotransfection of TRPV1 with v-Src resulted in fivefold increase in capsaicin-induced currents.
Gene_expression (cotransfection) of v-Src in embryonic kidney associated with qutenza
16) Confidence 0.06 Published 2004 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 15084474 Disease Relevance 0.09 Pain Relevance 0.40

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