INT294081

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.19
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANGPT1) signal transduction (ANGPT1) extracellular space (ANGPT1)
extracellular region (ANGPT1) plasma membrane (ANGPT1)
ANGPT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 5.00 Very Low Very Low Very Low
Thoracotomy 6 5.00 Very Low Very Low Very Low
positron emission tomography 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Perioperative pain 2 5.00 Very Low Very Low Very Low
colic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 135 96.08 Very High Very High Very High
Hypertension 14 90.64 High High
Pressure And Volume Under Development 34 46.96 Quite Low
Heart Rate Under Development 14 45.32 Quite Low
Renal Disease 20 38.56 Quite Low
Death 12 35.20 Quite Low
Cardiovascular Disease 4 32.24 Quite Low
Increased Venous Pressure Under Development 2 30.52 Quite Low
Disease 51 22.40 Low Low
Wound Infection 8 17.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As DRI reduces PRA, the production of Ang I decreases, resulting in less substrate availability for conversion to Ang II by ACE or other enzymes.
Negative_regulation (decreases) of Gene_expression (production) of Ang I
1) Confidence 0.04 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922316 Disease Relevance 0 Pain Relevance 0
In healthy humans, aliskiren of doses between 40 and 640 mg exerts a dose-dependent reduction in PRA, Ang I, and Ang II levels.
Negative_regulation (reduction) of Gene_expression (levels) of Ang I
2) Confidence 0.04 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922316 Disease Relevance 0.09 Pain Relevance 0
A recently completed study of more than 100 colorectal resection patients demonstrated that after either open or minimally invasive resection (on both PODs 1 and 3), Ang 1 levels were significantly lower and Ang 2 levels significantly higher compared with the preoperative results for both benign and cancer indications.
Negative_regulation (lower) of Gene_expression (levels) of Ang 1 associated with cancer
3) Confidence 0.03 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2814196 Disease Relevance 0.10 Pain Relevance 0

General Comments

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