INT294088

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.88
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ERBB2, ERBB4) cell proliferation (ERBB2, ERBB4) signal transduction (ERBB2, ERBB4)
nucleus (ERBB2, ERBB4) plasma membrane (ERBB2, ERBB4) nucleoplasm (ERBB4)
ERBB2 (Homo sapiens)
ERBB4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 21 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
opiate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 63 90.48 High High
Disease 85 89.40 High High
Toxicity 22 86.48 High High
Ovarian Cancer 50 81.12 Quite High
Carcinoma 3 79.64 Quite High
Advanced Or Metastatic Breast Cancer 28 69.00 Quite High
Fallopian Tube Neoplasms 3 59.12 Quite High
Breast Cancer 16 58.16 Quite High
Diarrhoea 30 30.92 Quite Low
Exanthema 22 30.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ErbB2, whilst having no exogenous ligand, is the preferred partner for heterodimerization with ErbB1, ErbB3 and ErbB4 as it amplifies the mitogenic signal with potent growth and survival effects.
ErbB2 Binding (heterodimerization) of ErbB4
1) Confidence 0.13 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004582 Disease Relevance 0.28 Pain Relevance 0
Pertuzumab is a monoclonal antibody that inhibits dimerization of ERBB2 with EGFR, ERBB3, and ERBB4.
ERBB2 Binding (dimerization) of ERBB4
2) Confidence 0.07 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2814233 Disease Relevance 0.60 Pain Relevance 0

General Comments

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