INT29411

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Context Info
Confidence 0.65
First Reported 1982
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 17
Disease Relevance 5.42
Pain Relevance 8.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ADRB2) plasma membrane (ADRB2) nucleus (ADRB2)
lysosome (ADRB2) cytoplasm (ADRB2) signal transducer activity (ADRB2)
Anatomy Link Frequency
A431 2
lymphocyte 2
neutrophils 2
myometrium 1
leukocytes 1
ADRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 83 99.80 Very High Very High Very High
Morphine 20 99.78 Very High Very High Very High
Central nervous system 2 99.70 Very High Very High Very High
Inflammation 340 99.66 Very High Very High Very High
agonist 91 99.56 Very High Very High Very High
Angina 2 99.48 Very High Very High Very High
Enkephalin 3 99.46 Very High Very High Very High
IPN 12 99.40 Very High Very High Very High
depression 2 98.84 Very High Very High Very High
mu opioid receptor 7 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 370 99.66 Very High Very High Very High
Cv General 3 Under Development 2 99.48 Very High Very High Very High
Depression 2 98.84 Very High Very High Very High
Neuropathic Pain 9 97.72 Very High Very High Very High
Cancer 20 96.96 Very High Very High Very High
Arrhythmogenic Right Ventricular Dysplasia 4 96.84 Very High Very High Very High
Necrosis 15 96.72 Very High Very High Very High
Squamous Cell Carcinoma 3 92.64 High High
Rheumatoid Arthritis 15 89.16 High High
Pulmonary Disease 5 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These experiments indicate: (i) that ouabain produces in guinea-pigs a pressor response which seems to be due to catecholamine release from the adrenal medulla probably by an action on the central nervous system; (ii) that the ventricular arrhythmias induced by ouabain are due in part to stimulation of the central nervous system leading to an increase in beta-adrenoceptor activity; (iii) that central alpha-adrenoceptors appear to be involved in the arrhythmogenic effects of ouabain, as clonidine reduced these effects.
Positive_regulation (increase) of beta-adrenoceptor in adrenal medulla associated with medulla, catecholamine, central nervous system, arrhythmogenic right ventricular dysplasia and clonidine
1) Confidence 0.65 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6122584 Disease Relevance 0.40 Pain Relevance 0.55
ICI 118,551 administration increased lymphocyte beta 2-adrenoceptor density and responsiveness by approximately 50%, whereas bisoprolol had no effect.
Positive_regulation (increased) of 2-adrenoceptor in lymphocyte
2) Confidence 0.59 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2830792 Disease Relevance 0.06 Pain Relevance 0.54
Sensitization of AC appears to be mediated solely by the increase in beta-2 AR numbers, because (+/-)-1-[2,3-(dihydro-7-methyl-1H-inden-4-yl)oxy]-3- [(1-methylethyl)amino]-2-butanol hydrochloride, which acts as an "inverse agonist" at the beta-2 AR, completely reversed elevated basal AC activities, and because the ratio between functional active beta-2 ARs and stimulatory G proteins remained unchanged.
Positive_regulation (increase) of beta-2 AR associated with agonist
3) Confidence 0.53 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8996236 Disease Relevance 0.22 Pain Relevance 0.70
Binding competition studies, transcripts and protein analysis were then performed to determine whether any changes in the number of ADRB2 and ADRB3 binding sites and in the transcript and protein expression might explain the observed change in the contractile response between non-pregnant and pregnant myometrium to ADRB2 and ADRB3 agonists.
Positive_regulation (response) of ADRB2 in myometrium associated with agonist
4) Confidence 0.50 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.05
Agonists of beta2-ARs, and more generally any molecule stimulating beta2-ARs such as beta-mimetics, are thus proposed as potential new treatments for neuropathic pain.
Positive_regulation (stimulating) of beta2-AR associated with neuropathic pain and agonist
5) Confidence 0.49 Published 2009 Journal Recent Pat CNS Drug Discov Section Abstract Doc Link 19538157 Disease Relevance 0.86 Pain Relevance 0.91
OBJECTIVE: To evaluate if exercise-induced ST-segment depression without typical angina pectoris is related to increases in sympatho-adrenal activity or beta-adrenoceptor sensitivity.
Positive_regulation (increases) of beta-adrenoceptor associated with angina and depression
6) Confidence 0.44 Published 2007 Journal J. Intern. Med. Section Abstract Doc Link 17241180 Disease Relevance 0.35 Pain Relevance 0.26
In conclusion, chronic exposure of clonal A431/ mu13 cells to morphine increases the capacity of stimulatory AC signaling by up-regulating beta-2 AR number.
Positive_regulation (up-regulating) of beta-2 AR in A431 associated with morphine
7) Confidence 0.44 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8996236 Disease Relevance 0.13 Pain Relevance 0.58
Chronic morphine treatment increases stimulatory beta-2 adrenoceptor signaling in A431 cells stably expressing the mu opioid receptor.
Positive_regulation (increases) of beta-2 adrenoceptor in A431 associated with mu opioid receptor, enkephalin and morphine
8) Confidence 0.44 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8996236 Disease Relevance 0.22 Pain Relevance 0.75
Dynamic exercise on a bicycle and infusion of graded doses of IPN led to an approximately 100% increase in lymphocyte beta 2-adrenoceptor density; this was abolished by ICI 118,551 but not affected by bisoprolol.
Positive_regulation (increase) of 2-adrenoceptor in lymphocyte associated with ipn
9) Confidence 0.40 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2830792 Disease Relevance 0.08 Pain Relevance 0.62
Our data show that morphine is able to exert a significant enhancement of the response of beta 2-adrenergic receptors to isoproterenol in human mononuclear leukocytes.
Positive_regulation (response) of 2-adrenergic in leukocytes associated with morphine
10) Confidence 0.14 Published 1995 Journal Biomed. Pharmacother. Section Abstract Doc Link 7749077 Disease Relevance 0 Pain Relevance 1.01
We investigated whether OPR stimulation influences the effects of beta-adrenergic receptor (beta-AR) stimulation in the isolated, isovolumic rat heart and whether the mechanism of such an interaction involves both beta-AR subtypes or an alteration in beta-AR-mediated increase in cAMP.
Positive_regulation (stimulation) of beta-adrenergic receptor in heart
11) Confidence 0.02 Published 1997 Journal Circulation Section Abstract Doc Link 9133523 Disease Relevance 0 Pain Relevance 0.35
Adenosine, through activation of the A2A receptor (A2AR) subtype, ranks among the most potent agents limiting the inflammatory activities of neutrophils.
Positive_regulation (activation) of A2AR in neutrophils associated with adenocard and inflammation
12) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2654409 Disease Relevance 0.89 Pain Relevance 0.51
In the present study, we used DNA microarray technology and real-time PCR to examine the impact of major anti-inflammatory signals, namely A2AR activation, prostaglandin E2 and elevated intracellular cyclic AMP, on the gene expression profile of human neutrophils stimulated by known inflammatory agonists.
Positive_regulation (activation) of A2AR in neutrophils associated with inflammation and agonist
13) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2654409 Disease Relevance 0.64 Pain Relevance 0.49
Depending on the gene, A2AR activation elicited transient (<2 h) or sustained (?
Positive_regulation (activation) of A2AR
14) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2654409 Disease Relevance 0.47 Pain Relevance 0.28
down-regulated by A2AR activation, which is in line with earlier findings [21], [23].
Positive_regulation (activation) of A2AR
15) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2654409 Disease Relevance 0.33 Pain Relevance 0.23
Recently, our laboratory reported that A2AR activation had a striking inhibitory impact on the in vitro and in vivo generation of tumor necrosis factor ?
Positive_regulation (activation) of A2AR associated with necrosis and cancer
16) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2654409 Disease Relevance 0.78 Pain Relevance 0.54
Furthermore, delta-i3L expression resulted in inhibition of delta-, mu-OR-, and alpha2AR-receptor-mediated cAMP accumulation, whereas the cAMP response produced by activation of the beta2-adrenergic receptor was unaffected, suggesting that the inhibitory effects of delta-i3L expression were selective for Gi/Go proteins.
Positive_regulation (activation) of beta2-adrenergic
17) Confidence 0.02 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16160084 Disease Relevance 0 Pain Relevance 0.41

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