INT294133

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.36
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NT5E) plasma membrane (NT5E) DNA metabolic process (NT5E)
cytoplasm (NT5E)
Anatomy Link Frequency
stem cell 6
synovium 2
NT5E (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 30 99.76 Very High Very High Very High
cytokine 126 89.72 High High
Inflammation 148 89.32 High High
Arthritis 31 83.20 Quite High
rheumatoid arthritis 16 42.16 Quite Low
COX2 12 5.00 Very Low Very Low Very Low
dexamethasone 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 175 99.44 Very High Very High Very High
Osteogenic Sarcomas 2 97.64 Very High Very High Very High
Chromosome Aberrations 3 85.88 High High
Arthritis 32 84.24 Quite High
Hypersensitivity 3 80.44 Quite High
Death 4 77.88 Quite High
Rheumatoid Arthritis 16 42.16 Quite Low
Obesity 9 41.72 Quite Low
Graft Vs Host Disease 15 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both the MSCs studied expressed stem cell markers CD73 and SSEA4 and their expression was not altered on treatment with IFN?
Regulation (stem cell) of Gene_expression (expressed) of CD73 in stem cell
1) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.29 Pain Relevance 0.18
Both the MSCs studied expressed stem cell markers CD73 and SSEA4 and their expression was not altered on treatment with IFN?
Neg (not) Regulation (altered) of Gene_expression (expressed) of CD73 in stem cell
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.30 Pain Relevance 0.18
Expression of CD73 and CD105 (Figure 4c) and CD90 (data not shown, off-scale fluorescence) in cultured synovium-derived cells was not affected by the procedure, as was the expression of CD146 in human osteosarcoma cells (Figure 4d).


Neg (not) Regulation (affected) of Gene_expression (Expression) of CD73 in synovium associated with osteogenic sarcomas
3) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.34 Pain Relevance 0.08
The expression of stem cell markers, CD73 and SSEA4 does not change significantly on treatment with either IFN?
Neg (not) Regulation (change) of Gene_expression (expression) of CD73 in stem cell
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.43 Pain Relevance 0.26

General Comments

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