INT294150

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.30
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTPRC)
Anatomy Link Frequency
T-lymphocytes 2
PTPRC (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 86 99.72 Very High Very High Very High
rheumatoid arthritis 22 96.24 Very High Very High Very High
cytokine 107 89.96 High High
chemokine 15 77.84 Quite High
Etanercept 12 66.80 Quite High
Inflammation 121 53.92 Quite High
metalloproteinase 2 52.04 Quite High
COX2 8 30.56 Quite Low
Infliximab 2 24.80 Low Low
cva 7 7.00 Low Low
Disease Link Frequency Relevance Heat
Renal Cancer 39 99.84 Very High Very High Very High
Experimental Arthritis 2 99.72 Very High Very High Very High
Malignant Neoplastic Disease 6 97.96 Very High Very High Very High
Skin Cancer 1 96.48 Very High Very High Very High
Rheumatoid Arthritis 26 96.24 Very High Very High Very High
Hypersensitivity 5 93.36 High High
Cancer 73 92.40 High High
Seronegative Spondarthritis 80 87.36 High High
Apoptosis 3 82.32 Quite High
Disease 51 72.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lower limit of CD45 expression is adapted from a CD34 vs.
Regulation (limit) of Gene_expression (expression) of CD45
1) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972200 Disease Relevance 0.53 Pain Relevance 0
Alterations in CD45 and CD3 ST expressions are in agreement with the decrease in the global cellular infiltration and T-lymphocytes, already found to be associated with active systemic anti TNF-?
Regulation (Alterations) of Gene_expression (expressions) of CD45 in T-lymphocytes
2) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945042 Disease Relevance 1.37 Pain Relevance 0.69
Co-culture with BMMSCs results in a transient up regulation of CD45RO levels at 24 hr with 1% BMMSCs and with IFN?
Regulation (regulation) of Gene_expression (levels) of CD45RO
3) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.06 Pain Relevance 0
blockers induced a significant down-regulation in CD45 (1157.0 ± 712.9 and 545.8 ± 253.2, P = 0.007) and CD3 (402.8 ± 203.0 and 224.8 ± 107.7, P = 0.039) ST expression.


Regulation (regulation) of Gene_expression (expression) of CD45
4) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945042 Disease Relevance 0.28 Pain Relevance 0.16
However, no definitive conclusions could be drawn from alterations in CD45RA expression data.
Regulation (alterations) of Gene_expression (expression) of CD45RA
5) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.08 Pain Relevance 0
We also have observed a down-regulation in the activity and expression of this glycoprotein in renal tumors, and in this sense our results agree with those described in the human melanoma [36].
Regulation (regulation) of Gene_expression (expression) of glycoprotein associated with renal cancer and skin cancer
6) Confidence 0.07 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.98 Pain Relevance 0.03

General Comments

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