INT29416

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Context Info
Confidence 0.47
First Reported 1987
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.52
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRD1) cytoplasm (OPRD1) signal transducer activity (OPRD1)
Anatomy Link Frequency
brain 2
OPRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 4 99.56 Very High Very High Very High
Serotonin 1 99.12 Very High Very High Very High
Potency 2 98.96 Very High Very High Very High
antagonist 8 98.80 Very High Very High Very High
Thalamus 1 88.00 High High
agonist 6 87.44 High High
midbrain 1 86.04 High High
MU agonist 2 84.92 Quite High
Endogenous opioid 1 79.84 Quite High
opioid receptor 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Eating Disorder 4 100.00 Very High Very High Very High
Genetic Predisposition To Disease 1 90.64 High High
Tics 1 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN).
Positive_regulation (restricting) of OPRD1 Binding (association) of associated with opioid, serotonin and eating disorder
1) Confidence 0.47 Published 2007 Journal Biol. Psychiatry Section Abstract Doc Link 16806108 Disease Relevance 0.45 Pain Relevance 0.15
The level of delta-receptor binding increases markedly during the third postnatal week in all brain areas examined.
Positive_regulation (increases) of delta-receptor Spec (examined) Binding (binding) of in brain
2) Confidence 0.42 Published 1987 Journal Brain Res. Section Abstract Doc Link 2830947 Disease Relevance 0 Pain Relevance 0.29
Analogues 4 and 9 exhibited delta antagonist potency similar to that of parent peptide 1, while compounds 5-8 and 10 showed 3-12-fold higher delta antagonist potency against DPDPE and deltorphin I and, in most cases, increased delta receptor affinity.
Positive_regulation (increased) of delta receptor Binding (affinity) of associated with antagonist and potency
3) Confidence 0.00 Published 1996 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 8956074 Disease Relevance 0.07 Pain Relevance 0.87

General Comments

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