INT29424

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Context Info
Confidence 0.56
First Reported 1984
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 4.58
Pain Relevance 4.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
CPA 2
gonadal 2
pituitary 2
sympathetic 2
Lhb (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 14 99.98 Very High Very High Very High
narcan 15 99.40 Very High Very High Very High
antagonist 7 99.12 Very High Very High Very High
opiate 10 98.72 Very High Very High Very High
Catecholamine 5 98.54 Very High Very High Very High
Kinase C 136 98.28 Very High Very High Very High
Opioid 11 96.72 Very High Very High Very High
Pain 1 93.84 High High
Clonidine 2 91.08 High High
Central nervous system 1 83.12 Quite High
Disease Link Frequency Relevance Heat
Stress 18 100.00 Very High Very High Very High
Rheumatic Heart Disease 13 99.84 Very High Very High Very High
Targeted Disruption 9 99.84 Very High Very High Very High
Hirsutism 31 98.04 Very High Very High Very High
Uterine Hemorrhage 1 93.64 High High
Hyperkalemia 2 91.96 High High
Stress Incontinence 12 91.52 High High
Anuria 1 90.36 High High
Renal Insufficiency 2 90.04 High High
Rheumatoid Arthritis 6 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pentobarbital anesthesia delayed, but did not prevent, the EB-induced LH surge in peripubertal females, while it completely abolished the P-induced LH surge.
Negative_regulation (abolished) of Positive_regulation (induced) of LH associated with anesthesia
1) Confidence 0.56 Published 1984 Journal Endocrinology Section Abstract Doc Link 6734515 Disease Relevance 0 Pain Relevance 0.10
The ovariectomy-induced increases in plasma FSH (p < 0.001) and LH (p < 0.05) levels were decreased in transgenic mice.
Negative_regulation (decreased) of Positive_regulation (increases) of LH in plasma associated with targeted disruption
2) Confidence 0.47 Published 1996 Journal Biol. Reprod. Section Abstract Doc Link 8722619 Disease Relevance 0.57 Pain Relevance 0.07
On the other hand, an injection of phenobarbital 14 hr before the expected ovulation blocked a preovulatory LH surge, even though the same drug failed to block photoinduced LH increase in females.
Negative_regulation (block) of Positive_regulation (increase) of LH
3) Confidence 0.41 Published 1988 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 3371646 Disease Relevance 0 Pain Relevance 0.09
However barbiturate anesthesia (pentobarbital and phenobarbital) administered on, before, or after the photosensitive phase did not block the LH increase by photostimulation.
Negative_regulation (block) of Positive_regulation (increase) of LH associated with anesthesia
4) Confidence 0.41 Published 1988 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 3371646 Disease Relevance 0 Pain Relevance 0.10
Pentobarbital anesthesia delayed, but did not prevent, the EB-induced LH surge in peripubertal females, while it completely abolished the P-induced LH surge.
Negative_regulation (prevent) of Positive_regulation (induced) of LH associated with anesthesia
5) Confidence 0.41 Published 1984 Journal Endocrinology Section Abstract Doc Link 6734515 Disease Relevance 0 Pain Relevance 0.10
Neither stress-induced glucocorticoid nor catecholamine release was responsible, since neither blockade of glucocorticoid secretion with the adrenal steroidogenesis inhibitor metyrapone nor blockade of catecholamine secretion with the sympathetic ganglionic blocking drug chlorisondamine prevented the stress-induced decline in serum LH concentrations.
Negative_regulation (prevented) of Positive_regulation (stress-induced) of LH in sympathetic associated with stress and catecholamine
6) Confidence 0.40 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2831246 Disease Relevance 0.50 Pain Relevance 0.64
In the luteal phase, after placebo administration, the frequency of LH pulses and mean LH levels were not modified, but both the amplitude of LH pulses (P < 0.025) and the LH response to GnRH were reduced (P < 0.02).
Negative_regulation (reduced) of Positive_regulation (response) of LH response
7) Confidence 0.40 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7883843 Disease Relevance 0 Pain Relevance 0.29
Administration of the opiate receptor antagonist naloxone (0.5 mg/kg BW), however, not only prevented the decline, but also transiently elevated serum LH concentrations, suggesting that opiates play a role in tonic as well as stress-induced decreases in LH secretion.
Negative_regulation (prevented) of Positive_regulation (elevated) of LH associated with stress, antagonist, narcan and opiate
8) Confidence 0.36 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2831246 Disease Relevance 0.50 Pain Relevance 0.69
Nose-snare caused a reduction in the propranolol-induced increase of LH pulse frequency and pulse amplitude.
Negative_regulation (reduction) of Positive_regulation (increase) of LH in Nose
9) Confidence 0.31 Published 2010 Journal Anim. Reprod. Sci. Section Abstract Doc Link 20462709 Disease Relevance 0.25 Pain Relevance 0.48
Pentobarbital anesthesia reduced the LH interpulse interval (increased the frequency) and increased mean LH levels.
Negative_regulation (reduced) of Positive_regulation (increased) of LH associated with anesthesia
10) Confidence 0.24 Published 2000 Journal Endocrinology Section Abstract Doc Link 10650931 Disease Relevance 0 Pain Relevance 0.14
In addition, reduced LH responses to GnRH were observed in cattle during transport.
Negative_regulation (reduced) of Positive_regulation (responses) of LH
11) Confidence 0.13 Published 1995 Journal J. Reprod. Fertil. Suppl. Section Abstract Doc Link 7623334 Disease Relevance 0.07 Pain Relevance 0.15
mol in combination with LH, the values on P4 accumulation became intermediate between those observe for basal and LH alone (Fig. 6); and the stimulatory effect of LH was completely eliminated by 1000 ?
Negative_regulation (eliminated) of Positive_regulation (effect) of LH
12) Confidence 0.12 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.03
to decrease LH-stimulated P4 accumulation was significantly (P < 0.05) inhibited in the PKC ?
Negative_regulation (was) of Positive_regulation (accumulation) of LH-stimulated associated with kinase c
13) Confidence 0.12 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.49
No difference were found in the LH increment after the GnRH stimulus in both group of patients before treatment; on the contrary, naltrexone administration reduced the LH response to GnRH in hyperinsulinemic women but failed to be effective in normoinsulinemic subjects.
Neg (failed) Negative_regulation (reduced) of Positive_regulation (response) of LH
14) Confidence 0.12 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8530590 Disease Relevance 0.25 Pain Relevance 0.37
Somewhat surprising was the inability of E2 treatment for 10 days to suppress circulating LH.
Negative_regulation (suppress) of Positive_regulation (circulating) of LH
15) Confidence 0.06 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548137 Disease Relevance 0 Pain Relevance 0
It is at present unclear if reduced circulating LH is a direct consequence of suppressed secretory activity of the gonadotropes or reduced output from the GnRH system.
Negative_regulation (reduced) of Positive_regulation (circulating) of LH
16) Confidence 0.06 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548137 Disease Relevance 0 Pain Relevance 0
In 30-day-implanted frogs, E2, but not DHT, significantly decreased the accumulation of LH in the pituitary (Fig. 3B).
Negative_regulation (decreased) of Positive_regulation (accumulation) of LH in pituitary
17) Confidence 0.06 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548137 Disease Relevance 0.14 Pain Relevance 0
Another unexpected observation was that DHT treatment for 30 days also suppressed circulating LH.
Negative_regulation (suppressed) of Positive_regulation (circulating) of LH
18) Confidence 0.06 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548137 Disease Relevance 0 Pain Relevance 0
Induced ovulators generally do not show "spontaneous" steroid-induced LH surges during their reproductive cycles, suggesting that the positive feedback actions of steroid hormones on GnRH release are reduced or absent in these species.
Negative_regulation (reduced) of Positive_regulation (induced) of LH
19) Confidence 0.04 Published 2000 Journal Front Neuroendocrinol Section Abstract Doc Link 10882541 Disease Relevance 0 Pain Relevance 0.03
LH response to LHRH was significantly decreased in RHD patients v. controls denoting delayed maturation of the hypothalamic-pituitary gonadal axis.
Negative_regulation (decreased) of Positive_regulation (response) of LH in gonadal associated with rheumatic heart disease
20) Confidence 0.03 Published 1997 Journal J. Trop. Pediatr. Section Abstract Doc Link 9078821 Disease Relevance 0.67 Pain Relevance 0.15

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