INT294290

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.46
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PROK1, IL11) extracellular space (IL11) cell-cell signaling (IL11)
cytoplasm (IL11)
Anatomy Link Frequency
decidua 4
epithelial cells 2
T cells 2
PROK1 (Homo sapiens)
IL11 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 35 100.00 Very High Very High Very High
metalloproteinase 14 89.40 High High
Pain 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Peripheral Arterial Disease 7 98.68 Very High Very High Very High
Down Syndrome 7 92.56 High High
Adhesions 14 70.08 Quite High
Lifespan 7 68.92 Quite High
Hyperplasia 7 48.96 Quite Low
Female Infertility 7 15.12 Low Low
Infection 21 13.60 Low Low
Pain 7 5.00 Very Low Very Low Very Low
Hematological Disease 7 5.00 Very Low Very Low Very Low
Spontaneous Abortion 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore PROK1–PROKR1 could increase IL-11 expression and secretion directly during decidualization in a complementary manner.
PROK1-PROKR1 Positive_regulation (increase) of Gene_expression (expression) of IL-11
1) Confidence 0.59 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.13 Pain Relevance 0.08
Since we have shown that PROK1 increases the expression and secretion of IL-11 we subsequently investigated whether PROK1 altered the expression levels of the receptors for IL-11—namely IL-11R?
PROK1 Positive_regulation (increases) of Gene_expression (expression) of IL-11
2) Confidence 0.59 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.06 Pain Relevance 0
PROK1 induces the expression and secretion of IL-11 but not PROKR1 or GP130 in first trimester decidua via a Gq–Ca2+–ERK dependent pathway
PROK1 Neg (not) Positive_regulation (induces) of Gene_expression (expression) of IL-11 in decidua
3) Confidence 0.43 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
Here, we have shown that PROK1–PROKR1 induces the expression of IL-11 in PROKR1 Ishikawa cells and first trimester decidua via the calcium–calcineurin signalling pathway in a guanine nucleotide-binding protein (Gq/11), extracellular signal-regulated kinases, Ca2+ and calcineurin–nuclear factor of activated T cells dependent manner.
PROK1-PROKR1 Positive_regulation (induces) of Gene_expression (expression) of IL-11 in T cells
4) Confidence 0.40 Published 2010 Journal Molecular Human Reproduction Section Abstract Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.05
RCAN1-4 overexpression inhibits PROK1-induced expression of IL-11
PROK1 Positive_regulation (induced) of Gene_expression (expression) of IL-11
5) Confidence 0.40 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.09 Pain Relevance 0
PROK1 induces the expression and secretion of IL-11 via a calcineurin–NFAT dependent pathway in Ishikawa endometrial epithelial cells
PROK1 Positive_regulation (induces) of Gene_expression (expression) of IL-11 in epithelial cells
6) Confidence 0.40 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.17 Pain Relevance 0
In the present study, we report that PROK1 induces the expression and secretion of the cytokine IL-11 in cultured endometrial epithelial cells and first trimester decidua explants.
PROK1 Positive_regulation (induces) of Gene_expression (expression) of cytokine IL-11 in decidua associated with cytokine
7) Confidence 0.37 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.09

General Comments

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