INT294291

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Context Info
Confidence 0.53
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PROK1, IL11) extracellular space (IL11) cell-cell signaling (IL11)
cytoplasm (IL11)
Anatomy Link Frequency
decidua 4
PROK1 (Homo sapiens)
IL11 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 98.24 Very High Very High Very High
metalloproteinase 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 3 2 48.56 Quite Low
Infection 6 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Female Infertility 2 5.00 Very Low Very Low Very Low
Hematological Disease 2 5.00 Very Low Very Low Very Low
Spontaneous Abortion 2 5.00 Very Low Very Low Very Low
Down Syndrome 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ablation of endogenous PROK1 in first trimester decidua inhibited IL-11 expression confirming that PROK1 regulates the basal expression and secretion of IL-11.
PROK1 Regulation (regulates) of Localization (secretion) of IL-11 in decidua
1) Confidence 0.53 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.05
IL-11 is known to be essential for successful decidualization and implantation and our data have characterised a novel pathway that regulates IL-11 secretion via PROK1-PROKR1 in human endometrium and first trimester decidua.


PROK1-PROKR1 Regulation (regulates) of Localization (secretion) of IL-11 in decidua
2) Confidence 0.23 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0

General Comments

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