INT294292

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Context Info
Confidence 0.53
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.42
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PROK1, IL11) extracellular space (IL11) cell-cell signaling (IL11)
cytoplasm (IL11)
Anatomy Link Frequency
decidua 4
endometrium 1
PROK1 (Homo sapiens)
IL11 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 30 80.00 Quite High
metalloproteinase 12 78.40 Quite High
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 12 90.40 High High
Reprotox - General 3 6 84.08 Quite High
Female Infertility 6 80.88 Quite High
Leukemia 6 18.60 Low Low
Infection 18 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Hyperplasia 6 5.00 Very Low Very Low Very Low
Hematological Disease 6 5.00 Very Low Very Low Very Low
Spontaneous Abortion 6 5.00 Very Low Very Low Very Low
Down Syndrome 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In accordance with our observation using the PROKR1 Ishikawa cell line, we showed that IL-11 in first trimester decidua is also regulated by PROK1, since treatment of decidua tissue with exogenous PROK1 increased IL-11 induction.
PROK1 Regulation (regulated) of IL-11 in decidua
1) Confidence 0.53 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.03
Importantly in the present study, we have mapped out the cellular and molecular pathways regulating IL-11 via PROK1 in endometrium and first trimester decidua.
PROK1 Regulation (regulating) of IL-11 in endometrium
2) Confidence 0.23 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.08 Pain Relevance 0
In conclusion, our data has mapped out for the first time, the intricate molecular mechanisms whereby IL-11 is regulated in endometrial epithelial cells and first trimester decidua by PROK1.
PROK1 Regulation (regulated) of IL-11 in decidua
3) Confidence 0.23 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.26 Pain Relevance 0.06
We further confirmed PROK1 regulation of IL-11 in first trimester decidua using miRNA constructs targeted to PROK1.
PROK1 Regulation (regulation) of IL-11 in decidua
4) Confidence 0.23 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.04
We found that PROK1–PROKR1 regulates IL-11 via the calcineurin signalling pathway in a guanine nucleotide-binding protein (Gq/11), calcium and extracellular signal-regulated kinase (ERK) dependent manner in human endometrium and first trimester decidua.
PROK1-PROKR1 Regulation (regulates) of IL-11 in decidua
5) Confidence 0.23 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.08 Pain Relevance 0
Overall we have identified and characterized the signalling components of a novel PROK1–PROKR1 signalling pathway regulating IL-11.



PROK1-PROKR1 Regulation (regulating) of IL-11
6) Confidence 0.23 Published 2010 Journal Molecular Human Reproduction Section Abstract Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.03

General Comments

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