INT294299

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (RCAN1) extracellular region (PROK1) nucleus (RCAN1)
DNA binding (RCAN1) cytoplasm (RCAN1)
RCAN1 (Homo sapiens)
PROK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 74.64 Quite High
metalloproteinase 4 30.56 Quite Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 6 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Female Infertility 2 5.00 Very Low Very Low Very Low
Hematological Disease 2 5.00 Very Low Very Low Very Low
Spontaneous Abortion 2 5.00 Very Low Very Low Very Low
Down Syndrome 2 5.00 Very Low Very Low Very Low
Reprotox - General 3 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover we have shown that overexpression of RCAN1-4 leads to a reduction in PROK1 induced IL-11 indicating that RCAN1-4 is acting as a negative regulator of PROK1–PROKR1 mediated IL-11 signalling as summarized in Fig. 6.
Gene_expression (overexpression) of RCAN1 Negative_regulation (reduction) of PROK1
1) Confidence 0.42 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
Overexpression of RCAN1-4 in PROKR1 Ishikawa cells using an adenovirus leads to a reduction in PROK1 induced IL-11 indicating that RCAN1-4 is a negative regulator in the calcineurin-mediated signalling to IL-11.
Gene_expression (Overexpression) of RCAN1 Negative_regulation (reduction) of PROK1
2) Confidence 0.42 Published 2010 Journal Molecular Human Reproduction Section Abstract Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.04

General Comments

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