INT294302

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.36
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PROK1, IL11) extracellular space (IL11) cell-cell signaling (IL11)
cytoplasm (IL11)
Anatomy Link Frequency
epithelial cells 2
PROK1 (Homo sapiens)
IL11 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 6 86.88 High High
cytokine 15 81.32 Quite High
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Peripheral Arterial Disease 3 98.68 Very High Very High Very High
Adhesions 6 71.20 Quite High
Lifespan 3 68.92 Quite High
Down Syndrome 3 64.00 Quite High
Female Infertility 3 16.24 Low Low
Infection 9 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Hyperplasia 3 5.00 Very Low Very Low Very Low
Hematological Disease 3 5.00 Very Low Very Low Very Low
Spontaneous Abortion 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PROK1 induces the expression and secretion of IL-11 via a calcineurin–NFAT dependent pathway in Ishikawa endometrial epithelial cells
PROK1 Positive_regulation (induces) of Localization (secretion) of IL-11 in epithelial cells
1) Confidence 0.40 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.17 Pain Relevance 0
Since we have shown that PROK1 increases the expression and secretion of IL-11 we subsequently investigated whether PROK1 altered the expression levels of the receptors for IL-11—namely IL-11R?
PROK1 Positive_regulation (increases) of Localization (secretion) of IL-11
2) Confidence 0.40 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.06 Pain Relevance 0
Therefore PROK1–PROKR1 could increase IL-11 expression and secretion directly during decidualization in a complementary manner.
PROK1-PROKR1 Positive_regulation (increase) of Localization (secretion) of IL-11
3) Confidence 0.40 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.13 Pain Relevance 0.08

General Comments

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