INT294309

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Context Info
Confidence 0.53
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 0.25
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PROK1, IL11) extracellular space (IL11) cell-cell signaling (IL11)
cytoplasm (IL11)
Anatomy Link Frequency
decidua 8
epithelium 3
stroma 1
PROK1 (Homo sapiens)
IL11 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 50 98.24 Very High Very High Very High
metalloproteinase 20 34.60 Quite Low
Pain 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 3 10 89.84 High High
Down Syndrome 10 82.32 Quite High
Infection 30 75.52 Quite High
Peripheral Arterial Disease 10 40.44 Quite Low
Leukemia 10 24.36 Low Low
Lifespan 10 10.68 Low Low
Adhesions 20 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Hyperplasia 10 5.00 Very Low Very Low Very Low
Female Infertility 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and PROKR1 in glandular epithelium and stroma suggesting the potential for PROK1–PROKR1 to regulate IL-11 expression in both compartments during endometrial receptivity and early pregnancy in an autocrine–paracrine manner.
PROK1-PROKR1 Regulation (regulate) of Gene_expression (expression) of IL-11 in epithelium
1) Confidence 0.53 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.04
In order to confirm the physiological relevance of our data, we investigated the effect of PROK1 on expression of IL-11 in first trimester decidua tissue explants.
PROK1 Spec (investigated) Regulation (effect) of Gene_expression (expression) of IL-11 in decidua
2) Confidence 0.53 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.03
These data indicate that IL-11 expression in Ishikawa cells is regulated via PROK1-PROKR1 and downstream activation of the Gq–calcium–ERK–calcineurin–NFAT signal transduction pathway.


PROK1-PROKR1 Regulation (regulated) of Gene_expression (expression) of IL-11
3) Confidence 0.39 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
Hence we investigated whether RCAN1-4 acts as a negative regulator for the PROK1 regulation of IL-11 expression and secretion.
PROK1 Regulation (regulation) of Gene_expression (expression) of IL-11
4) Confidence 0.39 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.08 Pain Relevance 0
We subsequently investigated whether PROK1 can regulate expression of IL-11 in first trimester decidua tissue explants.
PROK1 Regulation (regulate) of Gene_expression (expression) of IL-11 in decidua
5) Confidence 0.39 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
In this study, we have confirmed our initial human genome survey microarray observation that PROK1 regulates IL-11 expression (Evans et al., 2008).
PROK1 Regulation (regulates) of Gene_expression (expression) of IL-11
6) Confidence 0.23 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.09 Pain Relevance 0
Here, we have shown that RCAN1-4 is temporally regulated in a reciprocal manner to expression of IL-11 by PROK1–PROKR1.
PROK1-PROKR1 Regulation (regulated) of Gene_expression (expression) of IL-11
7) Confidence 0.23 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
We confirmed that PROK1 regulates expression of IL-11 in first trimester decidua using a targeted PROK1 miRNA lentivirus.
PROK1 Regulation (regulates) of Gene_expression (expression) of IL-11 in decidua
8) Confidence 0.23 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.08 Pain Relevance 0
Ablation of endogenous PROK1 in first trimester decidua inhibited IL-11 expression confirming that PROK1 regulates the basal expression and secretion of IL-11.
PROK1 Regulation (regulates) of Gene_expression (expression) of IL-11 in decidua
9) Confidence 0.23 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.05
and PROKR1 in glandular epithelium and stroma suggesting the potential for PROK1–PROKR1 to regulate IL-11 expression in both compartments during endometrial receptivity and early pregnancy in an autocrine–paracrine manner.
PROK1-PROKR1 Regulation (regulate) of in stroma Gene_expression (expression) of IL-11 in epithelium
10) Confidence 0.18 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.04

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