INT294346

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Context Info
Confidence 0.63
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 0.34
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (RCAN1) nucleus (RCAN1) DNA binding (RCAN1)
cytoplasm (RCAN1)
RCAN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 40 74.64 Quite High
metalloproteinase 16 44.64 Quite Low
Pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Down Syndrome 8 91.12 High High
Infection 24 5.00 Very Low Very Low Very Low
Adhesions 16 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Hyperplasia 8 5.00 Very Low Very Low Very Low
Female Infertility 8 5.00 Very Low Very Low Very Low
Hematological Disease 8 5.00 Very Low Very Low Very Low
Spontaneous Abortion 8 5.00 Very Low Very Low Very Low
Reprotox - General 3 8 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RCAN1-4 overexpression inhibits PROK1-induced expression of IL-11
Positive_regulation (overexpression) of Gene_expression (overexpression) of RCAN1
1) Confidence 0.63 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.09 Pain Relevance 0
RCAN1-4 is known to bind to calcineurin and previous studies have shown that overexpression of RCAN1-4 results in an inhibition of calcineurin activation of NFAT (Minami et al., 2004; Chan et al., 2005).
Positive_regulation (overexpression) of Gene_expression (overexpression) of RCAN1
2) Confidence 0.63 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.03
We have shown that treatment with 40 nM PROK1 maximally induces expression of RCAN1-4 mRNA by 1.5 h in a reciprocal manner to IL-11 (Fig. 2A) indicating that it could be a negative regulator of IL-11.
Positive_regulation (induces) of Gene_expression (expression) of RCAN1
3) Confidence 0.45 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.09 Pain Relevance 0
RCAN1-4 overexpression inhibits PROK1-induced expression of IL-11
Positive_regulation (overexpression) of Gene_expression (overexpression) of RCAN1
4) Confidence 0.45 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.09 Pain Relevance 0
Moreover we have shown that overexpression of RCAN1-4 leads to a reduction in PROK1 induced IL-11 indicating that RCAN1-4 is acting as a negative regulator of PROK1–PROKR1 mediated IL-11 signalling as summarized in Fig. 6.
Positive_regulation (overexpression) of Gene_expression (overexpression) of RCAN1
5) Confidence 0.45 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
RCAN1-4 is known to bind to calcineurin and previous studies have shown that overexpression of RCAN1-4 results in an inhibition of calcineurin activation of NFAT (Minami et al., 2004; Chan et al., 2005).
Positive_regulation (overexpression) of Gene_expression (overexpression) of RCAN1
6) Confidence 0.45 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.03
Overexpression of RCAN1-4 significantly reduced the PROKR1 mediated induction of IL-11 mRNA expression at 8 h (Fig. 2B; P < 0.01) and protein secretion at 12 h (Fig. 2C; P < 0.05) compared with cells infected with the control empty virus.


Positive_regulation (Overexpression) of Gene_expression (Overexpression) of RCAN1
7) Confidence 0.42 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.07 Pain Relevance 0
Overexpression of RCAN1-4 in PROKR1 Ishikawa cells using an adenovirus leads to a reduction in PROK1 induced IL-11 indicating that RCAN1-4 is a negative regulator in the calcineurin-mediated signalling to IL-11.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of RCAN1
8) Confidence 0.42 Published 2010 Journal Molecular Human Reproduction Section Abstract Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.04

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