INT294349

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.48
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PROKR1) signal transducer activity (PROKR1)
Anatomy Link Frequency
epithelial cell 1
endometrium 1
decidua 1
PROKR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 20 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 4 96.40 Very High Very High Very High
Spontaneous Abortion 4 87.16 High High
Peripheral Arterial Disease 4 86.28 High High
Infection 12 79.60 Quite High
Lifespan 4 56.52 Quite High
Hyperplasia 4 50.00 Quite Low
Adhesions 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Female Infertility 4 5.00 Very Low Very Low Very Low
Hematological Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we have recently shown that both PROK1 and PROKR1 expression levels are significantly higher in first trimester decidua compared with non-pregnant endometrium (Evans et al., 2008).
Gene_expression (expression) of PROKR1 in decidua
1) Confidence 0.50 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.08 Pain Relevance 0
Using epithelial cells stably expressing PROKR1 we have shown that PROK1 regulates genes known to have important roles within the endometrium during implantation and early pregnancy.
Gene_expression (expressing) of PROKR1 in endometrium
2) Confidence 0.50 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.07 Pain Relevance 0
In order to investigate the molecular mechanisms whereby PROK1 mediates the induction of IL-11, we made use of a human endometrial epithelial cell line, Ishikawa cells, stably expressing PROKR1 (Evans et al., 2008).
Gene_expression (expressing) of PROKR1 in epithelial cell
3) Confidence 0.50 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.14 Pain Relevance 0
Stable PROKR1 transfected cells were designed and characterized as described before (Evans et al., 2008).
Gene_expression (transfected) of PROKR1
4) Confidence 0.44 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.18 Pain Relevance 0

General Comments

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