INT294370

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.54
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Niacr1) plasma membrane (Niacr1) signal transducer activity (Niacr1)
Anatomy Link Frequency
cochlea 1
brain 1
Niacr1 (Mus musculus)
Pain Link Frequency Relevance Heat
sSRI 36 75.96 Quite High
Central nervous system 13 73.44 Quite High
Serotonin 23 70.64 Quite High
fluoxetine 17 64.32 Quite High
depression 56 60.08 Quite High
antidepressant 90 55.52 Quite High
gABA 9 50.00 Quite Low
Neurotransmitter 5 45.28 Quite Low
monoamine 17 5.48 Low Low
agonist 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 70 99.86 Very High Very High Very High
Disorder Of Lipid Metabolism 301 97.84 Very High Very High Very High
Hypoalphalipoproteinemias 16 94.32 High High
Disease 103 86.40 High High
Congenital Anomalies 8 84.12 Quite High
Pressure And Volume Under Development 5 79.72 Quite High
Cardiovascular Disease 7 79.52 Quite High
Dementia 11 79.36 Quite High
Insulin Resistance 2 79.00 Quite High
Abdominal Obesity 1 78.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to the guidelines, niacin is the preferred agent for use in combination with statins because of the availability of greater evidence for CHD event reduction with niacin compared with fibrates.26

General management of low HDL

Negative_regulation (reduction) of niacin associated with coronary heart disease and disorder of lipid metabolism
1) Confidence 0.24 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.61 Pain Relevance 0
Therefore, loss of efferent, nicotinic receptor-based cholinergic activity may alter the critical period of functional maturation of the cochlea, as has been suggested upon examination of the spatiotemporal innervation characteristics of the ?
Negative_regulation (loss) of nicotinic receptor in cochlea
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816210 Disease Relevance 0 Pain Relevance 0.07
A recent study reports that the acute administration of citalopram reduced glucose metabolism in the brain while the concomitant administration of acetylcholinesterase inhibitor and nicotinic receptor modulator (galantamine) and citalopram have increased glucose metabolism.
Negative_regulation (inhibitor) of nicotinic receptor in brain
3) Confidence 0.01 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2845130 Disease Relevance 0.77 Pain Relevance 0.35

General Comments

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